Heat shock protein 60 (HSP60) is a mitochondrial chaperonin that plays a role in the transportation and refolding of proteins from the cytoplasm into the mitochondrial matrix. HSP60’s amino acid sequence bears a similarity to its homolog in plants, bacteria, and humans. Chlamydia is an obligate intracellular bacterium. Chlamydia HSP60 (C.Hsp60) is associated with the outer membrane complexes of Chlamydia and appears to be responsible for proinflammatory pathologic manifestations. Autoimmune disease can be induced by specific antigens such as HSPs, since antibodies against bacterial HSPs can cross-react with human HSP60 and induce cytotoxic damage to the stressed endothelial cells.
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Increased risk of multiple autoimmunities including arthritis, lupus, gastrointestinal disorders, lung disorders, heart autoimmunity, and neuroautoimmunity.
Heat shock protein 60 (HSP60) is a mitochondrial chaperonin that plays a role in the transportation and refolding of proteins from the cytoplasm into the mitochondrial matrix. HSP60’s amino acid sequence bears a similarity to its homolog in plants, bacteria, and humans. Chlamydia is an obligate intracellular bacterium. Chlamydia HSP60 (C.Hsp60) is associated with the outer membrane complexes of Chlamydia and appears to be responsible for proinflammatory pathologic manifestations. Autoimmune disease can be induced by specific antigens such as HSPs, since antibodies against bacterial HSPs can cross-react with human HSP60 and induce cytotoxic damage to the stressed endothelial cells.
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Acinetobacter, Aspergillus, Babesia + Ehrlichia + Bartonella, Blastocystis hominis, Borrelia burgdorferi, Campylobacter jejuni, Candida albicans, Chlamydias, Citrullinated EBV, Clostridium difficile, Cryptosporidium, CYP450, mimic Hepatitis C Peptide, Cytomegalovirus, Entamoeba histolytica, Giardia lamblia, Helicobacter pylori, Human + Chlamydia HSP-60, Human Herpesvirus-6, Klebsiella, Mycobacterium avium, Mycoplasmas, Penicillium, Porphyromonas gingivalis, Rotavirus, Stachybotrys chartarum, Streptococcal M Protein, Streptococcus mutans, Streptozymes, Yersinia enterocolitica