Like all cells in the human body, red blood cells experience a life cycle of creation, maturation, and then destruction. When a red blood cell has reached the end of its life, it is broken down into its base components—one of which is bilirubin, a yellow pigment. The bilirubin will then circulate through the blood on its way to the liver where it will be excreted into the bile duct and stored in our gall bladder. Eventually, it will be released into the small intestine to aid in the digestion of fats and ultimately is excreted in stool. There are two forms of bilirubin that can be measured by a blood test: conjugated (direct) and unconjugated (indirect). All of the bilirubin in our body together is called “total” bilirubin. “Direct” or “conjugated” bilirubin indicates that a sugar has been attached to it. “Indirect” or “unconjugated” bilirubin indicates the absence of a sugar. The important distinction is that direct bilirubin is water soluble, while indirect bilirubin is not. Blood tests to assess bilirubin will measure total, direct, and indirect. Comparing the three results will provide information regarding any conditions that may be present, including: damage to the liver, liver disease, jaundice (yellowing of the skin / eyes), and cancer of the gallbladder or pancreas.
Normal Ranges in µmol/L:
0-15 days: 0-0.6
15-30 days: 0.0-0.3
>30 days: 0-0.5
A low level of direct bilirubin in the blood is not a cause for concern. There are some medicines (like vitamin C) that can cause bilirubin levels to drop, but there are no detrimental effects associated with this.
In adults, an elevated level of direct bilirubin typically points to a blockage or disease of the liver, bile ducts, or gallbladder. Possible diseases include: viral hepatitis, cancer of the liver, and alcoholic liver disease. Blockages are usually caused by gallstones, tumors, or scarring.
In newborn babies, infant jaundice (yellow discoloration of the skin caused by an excess of bilirubin) isn’t unusual and typically resolves within a few days or weeks; however, a bilirubin level that remains elevated in an infant can indicate a variety of physiological issues, including: blood type incompatibility with the mother, an infection of the blood, viral or bacterial infection, and liver disease.
Own it for life
Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
billed every month
Data entry included
$6.60/month billed annually
Data entry included
own it for life
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Monthly Plus
for health professionals
$75 per month