Alpha-1-Globulin, Serum

Optimal Result: 0 - 0.4 g/dL, or 0.00 - 4.00 g/L.

Protein in the serum is made up of albumin (∼ 60%) and globulin.

Globulins are divided into alpha-1, alpha-2, beta, and gamma globulins.

Globulins are made in your liver by your immune system. They play an important role in liver function, blood clotting, and fighting infection. In general, alpha and gamma globulin protein levels increase when there is inflammation in the body.

What does it mean if your Alpha-1-Globulin, Serum result is too low?

Alpha-1 antitrypsin deficiency (a genetic disorder that may result in lung disease or liver disease)

What does it mean if your Alpha-1-Globulin, Serum result is too high?

Increased alpha-1 globulin proteins may be due to:

  • Acute inflammatory disease
  • Chronic inflammatory disease (for example, rheumatoid arthritis, SLE)
  • Cancer
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