Other names: 4-Methoxy Estrone, 4-Methoxyestrone, 4-ME1, 4-ME-E1
Healthy Phase II metabolism methylates 2-hydroxy (2-OH) estrogens to the more cancer-protective 2-methoxy (2-MeO) forms, and neutralizes the potentially carcinogenic 4-OH estrogens to their 4-MeO forms.
Neutralized version of carcinogenic 4-OH-E1 (via methylation in Phase II)
4-OHE1 is less likely to oxidize to carcinogenic compounds if neutralized by COMT. COMT catalyses the shift of a methyl group from the co-enzyme S-adenosyl-L-methionine (SAMe) to one hydroxyl group of the catechols with Mg2+ acting as a co-factor.
COMT uses SAMe as its methyl donor; therefore, maintaining SAMe availability will encourage COMT activity
– Methionine (especially important if low homocysteine)
– Magnesium
– B2, B6, B12
– Folic acid (also as folinic acid, 5-formyl THF, or 5-methyl THF)
– TMG (betaine)
------------------------
4-Methoxyestrone (4-ME1) is an endogenous, naturally occurring methoxylated catechol estrogen and metabolite of estrone that is formed by catechol O-methyltransferase via the intermediate 4-hydroxyestrone. It has estrogenic activity similarly to estrone and 4-hydroxyestrone. Estrone is a steroid, a weak estrogen, and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estriol. Estrone, as well as the other estrogens, are synthesized from cholesterol and secreted mainly from the gonads, though they can also be formed from adrenal androgens in adipose tissue. Relative to estradiol, both estrone and estriol have far weaker activity as estrogens. Estrone can be converted into estradiol and serves mainly as a precursor or metabolic intermediate of estradio.
- Low levels of the methoxy-estrogens in the presence of normal or high hydroxylated estrogens usually indicates poor methylation.
- Low levels may be associated with an increased breast cancer risk.
Elevated methoxy-estrogens, particularly the 4-methoxy-estrogens (4-MeO-E2 and 4-MeO-E1) are beneficial if the 4-hydroxylated precursors are also high.
$79 per year
$6.60 per month billed annually
Use promocode
$79 per year
$250 single payment
$45 per month
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.
Learn MoreAt HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
16a-OH Estrone, 2-MeO E1/2-OH E1, 2-MeO Estradiol, 2-MeO Estrone, 2-OH (E1 + E2)/16-a- OH E1, 2-OH Estradiol, 2-OH Estrone, 20a- Dihydroprogesterone, 3a- Dihydroprogesterone, 4-MeO E1/4-OH E1, 4-MeO E2/4-OH E2, 4-MeO Estradiol, 4-MeO Estrone, 4-OH Estradiol, 4-OH Estrone, 5a,3a-Androstanediol, 5a-DHT, Allopregnanediol, Allopregnanolone, Androstenedione, Androsterone, Bisphenol A, Corticosterone, Cortisol/Cortisone, Creatinine (1st morning), Creatinine (2nd morning), Creatinine (Evening), Creatinine (Night), Creatinine (pooled), Deoxycorticosterone, DHEA, E3/(E1+E2), Epi-Testosterone, Estradiol, Estriol, Estrone, Etiocholanolone, Free Cortisol (1st Morning), Free Cortisol (2nd Morning), Free Cortisol (Evening), Free Cortisol (Night), Free Cortisone (1st Morning), Free Cortisone (2nd Morning), Free Cortisone (Evening), Free Cortisone (Night), Melatonin (1st Morning), Melatonin (2nd Morning), Melatonin (Evening), Melatonin (Night), Pgdiol/E2, Pregnanediol, T/Epi-T, Testosterone, Tetrahydrocortisol, Tetrahydrocortisone, Total Cortisol, Total Cortisone