20a-Dihydroprogesterone (20a-DHP), also known as 20a-hydroxyprogesterone (20a-OHP), is a naturally occurring, endogenous progestogen. It is a metabolite of progesterone, formed by the 20a-hydroxysteroid dehydrogenases (20a-HSDs). 20a-DHP can be transformed back into progesterone by 20a-HSDs. 20a-DHP has very low affinity for the progesterone receptor and is much less potent as a progestogen in comparison to progesterone.
3a- and 20a- dihydroprogesterone, have tumor-inhibitory properties in breast cancer.
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Elevated results of 20a-Dihydroprogesterone in an Advanced Dried Urine Hormone Profile can indicate several potential health implications:
→ Hormonal Imbalance: An elevated level of 20a-Dihydroprogesterone may suggest a hormonal imbalance. This hormone is a metabolite of progesterone, and its increase could indicate irregularities in the female reproductive hormones.
→ Menstrual Irregularities: Hormonal imbalances involving 20a-Dihydroprogesterone can contribute to menstrual irregularities, including heavy or irregular periods, and may be associated with conditions such as Polycystic Ovary Syndrome (PCOS).
→ Fertility Issues: Hormonal imbalances can affect fertility. Elevated 20a-Dihydroprogesterone levels might be related to difficulties in conceiving.
→ Endocrine Disorders: In some cases, elevated levels of 20a-Dihydroprogesterone could be associated with underlying endocrine disorders or adrenal dysfunction.
Further Evaluation: It's essential to consult a healthcare provider if you have elevated results of 20a-Dihydroprogesterone in your hormone profile. They can conduct further assessments and recommend appropriate treatments or interventions based on the specific context of your health and symptoms.
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