Androsterone is the product of androgens metabolized by 5-alpha reductase. It acts as a neurosteroid and a weak potentiator of GABA-A receptor activity.
Androsterone is the product of androgens metabolized by 5-alpha reductase. It acts as a neurosteroid and a weak potentiator of GABA-A receptor activity. Inhibiting 5-alpha reductase lowers AN. 24-hour urine testing has shown that AN declines along with DHEA. Low levels may also be associated with adrenal insufficiency, anorexia nervosa and panhypopituitarism.
Androsterone is the product of androgens metabolized by 5-alpha reductase. It acts as a neurosteroid and a weak potentiator of GABA-A receptor activity. Androsterone may also be converted to DHT via backdoor pathway using HSD3B and HSD17B making it a metabolic intermediate. Potential causes of AN elevation may include PCOS, over supplementation of DHEA or pregnenolone, androgen producing gonadal tumors, congenital adrenal hyperplasia, adult-onset adrenal hyperplasia, serious illness, shock, and burns.
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