The DUTCH test measures the total of testosterone glucuronide and testosterone sulfate. These conjugates of testosterone are formed mostly from bioavailable testosterone that undergoes phase 2 metabolism to make it ready for urine excretion.
Testosterone glucuronide is mostly made by the UGT2B17 enzyme, which also makes the glucuronide forms of 5a-DHT and 5b-androstanediol. Genetic variants of this enzyme reduce the urinary levels of these hormones without affecting serum levels. The genetic variants of UGT2B17 vary in the population from 7-80% (variation dependent on genetic ancestry, with the highest rates in those of Asian descent). Heterozygous individuals show milder reductions in urinary testosterone than homozygous. For this reason, low and very low levels of urinary testosterone should be confirmed with serum testing before treatment is applied. Serum testing can include free and total testosterone and SHBG.
The testes make most of the male's testosterone. Levels tend to be their highest at around 20 years of age and start to decline when men get into their 30's. Levels continue to drop as men age. Testosterone is needed for building bones and muscle mass, regulating body fat distribution and in the production of sperm and red blood cells. Testosterone is also important for libido and downstream production of modest amounts of estrogen.
Testosterone levels in healthy men vary widely so it is suggested that these ranges be interpreted with caution and consideration of symptoms. In addition, because estrogen also supports libido, erections and healthy weight management, estrogen levels should be considered along with the testosterone levels when assessing symptoms.
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Testosterone in Women
The main male sex hormone, testosterone is also important for women. Optimizing testosterone in women with low or low-normal levels may improve poor libido, vaginal dryness, muscle mass, and overall sense of optimism and well-being. Low levels may be due to low DHEA precursor or adrenal stress. High levels are common in PCOS or may be a sign of over-supplementation.
Testosterone in Men
Lower levels in men are increasingly common and can lead to fatigue, apathy, loss of muscle mass and strength. Low or low normal levels in young to middle aged men can be an indicator of environmental toxicity. High levels are rarely seen except in cases of over-supplementation. Testosterone metabolizes to more potent androgens via 5α-reductase and aromatizes to estradiol. Testosterone in men should be evaluated in relationship to estrogens in order to evaluate possible over-aromatization.
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A high testosterone level in men may indicate:
- Testicular tumors
- Adrenal tumors producing testosterone
- Use of anabolic steroids
- Early puberty
- Congenital adrenal hyperplasia affecting the adrenal glands
Increased testosterone in women may be caused by:
- Ovarian or adrenal gland tumor
- Polycystic ovary syndrome
- Congenital adrenal hyperplasia affecting the adrenal glands
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A low testosterone level in men may be due to:
- Hypothalamic or pituitary disease
- A genetic condition causing decreased testosterone production in young men
- Testicular failure / infertility, which can be genetic (myotonic dystrophy) or due to impairment (alcoholism, physical injury, or the mumps)
- A chronic disease like diabetes
Talk to your doctor about possible treatment options. Here are a few natural ways that have shown to increase testosterone in men:
- Getting enough sleep (7 to 8 hrs / night)
- Maintain a healthy diet
- Lose weight (Losing excess weight can bring testosterone back up.)
- Stay active (Sedentary men tend to have reduced levels of testosterone, as the body doesn’t need as much. Weightlifting can stimulate testosterone production.)
- Reduce stress
- Get to a optimal vitamin D level
- Talk to GP about DHEA, Vit D, Magnesium, Zinc supplementation
- Review existing medications (Medication can be one of the most common reasons for low testosterone levels)
- Avoid drugs and alcohol
- Avoid BPA (=endocrine disruptor)
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If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we do talk about popular labs, we welcome reports from lots of other places too. It's as simple as this: if you can get a test done, you can upload it to Healthmatters. We can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
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1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
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Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
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