Optimal Result: 12 - 30 ng/mg.

5a-Androstanediol is a testosterone metabolite that is more androgenic than b-Androstanediol. It is metabolized via the 5-alpha metabolic pathway (= increased 5α-reductase activity). In contrast, the 5-beta metabolism makes androgens less potent.

Increased 5a-reductase activity may be accompanied by clinical signs of androgenicity (excess facial hair growth, scalp hair loss, acne, irritability, oily skin, prostate issues in men...etc). 

It's important to look at this marker and compare it to 5b-Androstanediol. If your 5a-Androstanediol (this marker) and 5a-DHT are increased and 5b-Androstanediol is normal to low then you can do things to lower the preference of your body to move towards that 5-alpha metabolic pathway. 

If your overall testosterone is elevated as well, please refer to the main testosterone biomarker as you have to address the overall testosterone level and which pathway (alpha vs. beta) your body is choosing.

Technically, 5a-Androstanediol can also be formed from DHEA metabolites without going through the testosterone pathway, but they generally tend to correlate with testosterone production.

What does it mean if your 5a-Androstanediol result is too low?

Androgen deficiency can lead to:

- decreased sexual function

- vaginal dryness

- fatigue

- depression

- bone loss

What does it mean if your 5a-Androstanediol result is too high?

If your 5a-Androstanediol and 5a-DHT levels are increased, and your overall testosterone levels are normal (or even high) then your body is leaning towards the more androgenic 5-alpha metabolism pathway.

Possible symptoms:

If you are going down the alpha pathway towards 5a-DHT/ 5a-Androstanediol (= elevated values), the symptoms are usually your typical PCOS-like symptoms like facial hair, acne, anger and irritation and hair loss on the head. Males might experience pattern baldness, prostate enlargement (BPH = Benign prostatic hyperplasia). You might have completely normal levels of testosterone (please check your testosterone marker in this test to verity) and, yet, have a bad case of acne, are irritated or thinning scalp hair. If your 5a- DHT / 5a-Androstanediol is increased this would be an indication that you are favoring the alpha pathway that’s quite aggressive on your skin, hair and other places.

How to potentially address increased 5-alpha pathway preference:

The reasons for your body choosing the alpha pathway can certainly be genetic, but it is often due to inflammation, blood sugar / insulin dysregulation, having extra adipose tissue, etc.. If you can address these underlying issues then your body will balance out the alpha and beta pathways and it will improve the symptoms. 

In addition to addressing the underlying conditions (inflammation, glucose/insulin dysregulation, etc), there are things that can be done from a lifestyle perspective to mitigate the symptoms by blocking the alpha pathway, such as:

(before starting a supplement regime, please consult your doctor first)

- Zinc

- Saw palmetto

- Stinging and dwarf nettle

- Pygeum extract (bark)

- Reishi mushroom

Understand blood, stool, and urine medical results from your labs.

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Get 10% off of your first yearly or monthly plan.

Use promocode

Essential Plan


  • Monthly subscription
  • Instant interpretation
  • Use the free self-upload form
  • Additional charge for upload service
  • 2000+ biomarkers explained
  • Recommendations
  • Cancel anytime

Advanced Plan


  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 2000+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium plan


  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 2000+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Healthmatters.io software for professional use.

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.

Learn More


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals
×

Understand Your Lab Result Now

  • Instant interpretation
  • 2000+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode:

;