The trace mineral selenium functions primarily as a component of the antioxidant enzyme, glutathione peroxidase. Glutathione peroxidase activity, which requires selenium for activity, facilitates the recycling of vitamins C and E, in optimizing the performance of the antioxidant system. Low levels of selenium have been linked to a higher risk for cancer, cardiovascular disease, inflammatory diseases, and other conditions associated with free radical damage, including aging and cataract formation. Selenium is also essential for healthy cell-mediated immune function, stimulating immune properties of lymphocytes. Selenium is also needed for the activation of thyroid hormones.
Deficiency Symptoms: Chronic low selenium intake is associated with an increased risk for heart disease, cancer and depressed immune function. Selenium appears to provide protection against heart disease and stroke. Selenium supplementation (100 ugm/day) increases the ratio of HDL to LDL and inhibits platelet aggregation. Selenium and glutathione peroxidase activity are low in patients with rheumatoid arthritis, eczema, psoriasis and most inflammatory conditions. This is related to the increased synthesis of proinflammatory prostaglandins and leukotrienes. Immune system function is enhanced by selenium, by contributing to higher natural killer cell (NKC) activity. Natural killer cells have the ability to destroy cancer cells and bacterial and viral agents. Heavy metal toxicity symptoms may be alleviated by selenium, acting as an antagonist. Selenium deficiency may also contribute to male infertility.
Repletion Information: Selenium is safe at the level generally used for supplementation (100-200 mcg/day). However, taking more than 750 mcg of selenium per day may cause toxicity.
Reactions such as loss of fingernails, skin rash, and neurological aberrations. In the presence of iodine deficiency goiter, selenium supplementation has been reported to exacerbate low thyroid function.
Selenium is available in several different forms. Studies indicate that inorganic salts like sodium selenite are less effectively absorbed and not as biologically active as organic forms of selenium, such as selenomethionine or high-selenium content yeast.
Highest sources of dietary selenium are found in:
- Wheat Germ
- Brazil Nuts
- Red Swiss Chard
- Whole Wheat Bread
- Brown Rice
The adult RDA for selenium is 50ug/day.
Own it for life
Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
billed every month
Data entry included
$6.60/month billed annually
Data entry included
own it for life
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Monthly Plus
for health professionals
$75 per month