Based on a recent study of an 'apparently healthy' and non-metabolic syndrome population, the following cut-offs have been defined for
OxLDL:
- A cut-off of <60 U/L defines a population with a low relative risk of developing metabolic syndrome,
- A range of 60 to 69 U/L defines a population with a moderate relative risk (2.8 fold) and
- Levels equal or greater than 70 U/L defines a population with a high relative risk (3.5-fold).
-----------------------
Metabolic syndrome (MetS) represents a cluster of risk factors for cardiovascular disease (CVD), defined by the presence of ≥3 of the following 5 physiological risk factors:
- increased waist circumference,
- elevated blood pressure,
- low HDL cholesterol,
- elevated triglycerides,
- and elevated glucose.
Despite established diagnostic and treatment guidelines for MetS, the clinical evidence guiding the use of markers to predict MetS onset is still evolving.
One potential marker of MetS risk is oxidized LDL (oxLDL), which is formed when oxidative stress leads to modification of the apoB subunit on LDL cholesterol (LDL). Conversion of LDL to oxLDL appears to be an important event that helps initiate and accelerate the development of early atherosclerotic lesions, or fatty streaks. Cardiovascular sequelae of elevated oxLDL include coronary artery disease, acute myocardial infarction, stable and unstable angina, and untreated overt hypothyroidism. In a cross-sectional study of 3,987 non-diabetic individuals without symptoms of atherosclerosis, elevated oxLDL was strongly associated with prevalent MetS: odds ratios for the highest quartile ranged from 2.57 (95% CI 1.66-4.04) to 3.36 (95% CI 2.33-4.91), depending on which variables were adjusted for.
Measurement of oxLDL can also help in assessing the risk of MetS. A prospective, longitudinal study looked at oxLDL levels in 1,367 initially healthy adults in Finland. Individuals with elevated baseline oxLDL levels were more likely to develop MetS at 6-year follow-up, after adjusting for age, sex, smoking status, insulin resistance, body mass index, and C-reactive protein; however, the trend was not significant after also adjusting for apoB.
Similar findings were reported in another prospective, longitudinal study of 1,889 initially healthy adults in the United States. At 5-year follow-up, individuals in the highest quintile of oxLDL at baseline had 3.5 times the risk of developing MetS compared to those in the lowest quintile; individuals in the fourth quintile were at moderate risk (OR=2.8) for MetS.
Reference:
- Holvoet et al. JAMA. 2008; 299: 2287-2293 [L]
- Moore JX, Chaudhary N, Akinyemiju T. Metabolic syndrome prevalence by race/ethnicity and sex in the United States, National Health and Nutrition Examination Survey, 1988-2012. Prev Chronic Dis. 2017;14:4-5.
- Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol. A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. 2018:25709.
- Srikanthan K, Feyh A, Visweshwar H, et al. Systematic review of metabolic syndrome biomarkers: a panel for early detection, management, and risk stratification in the West Virginian population. Int J Med Sci. 2016;13:25-38.
- Gruzdeva O, Uchasova E, Dyleva Y, et al. Multivessel coronary artery disease, free fatty acids, oxidized LDL and its antibody in myocardial infarction. Lipids Health Dis. 2014;13:111.
- Salvayre R, Negre-Salvayre A, Camaré C. Oxidative theory of atherosclerosis and antioxidants. Biochimie. 2016;125:281-296.
- Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem. 1997;272:20963-20966.
- Oge A, Sozmen E, Karaoglu AO. Effect of thyroid function on LDL oxidation in hypothyroidism and hyperthyroidism. Endocr Res. 2004;30:481-489.
- Hurtado-Roca Y, Bueno H, Fernandez-Ortiz A, et al. Oxidized LDL is associated with metabolic syndrome traits independently of central obesity and insulin resistance. Diabetes. 2017;66:474-482.
- Koskinen J, Magnussen CG, Würtz P, et al. Apolipoprotein B, oxidized low-density lipoprotein, and LDL particle size in predicting the incidence of metabolic syndrome: the Cardiovascular Risk in Young Finns study. Eur J Prev Cardiol. 2012;19:1296-1303.
- Holvoet P, Lee DH, Steffes M, et al. Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome. JAMA. 2008;299:2287-2293.
- Harmon ME, Campen MJ, Miller C, et al. Associations of circulating oxidized LDL and conventional biomarkers of cardiovascular disease in a cross-sectional study of the Navajo population. PLoS One. 2016;11:e0143102.
Keeping track of your medical data and laboratory results while understanding what they mean empowers positive health outcomes.
Keeping track of your medical data and lab results while understanding what they mean empowers positive health outcomes.
Save 10% off any plan with promo-code:
HEALTH10
Researchers have found that individuals with high levels of oxidized LDL are 4x more likely to develop metabolic syndrome up to five years following testing. In particular, increased oxidized LDL levels were associated with abdominal obesity and high triglyceride levels, as well as high blood glucose. The oxidized LDL test can also help your medical provider decide if you may be at a higher risk for heart attack or heart disease than by looking at traditional risk factors alone. Oxidized LDL may be twice as good at helping your medical provider know your risk for heart disease as any one of the traditional risk factors.
What can you do to help lower your oxidized LDL levels?
- Lifestyle changes are the best option to help lower your oxidized LDL levels.
- If you smoke, ask your medical provider to help you quit. It is not easy but there are programs and strategies (including over-thecounter and prescription medications) that can improve your chance of success.
- Adjust your diet to include foods low in saturated fat and those with zero trans-fat. Fruits and vegetables are also great options as they contain anti-oxidants.
- Talk with your medical provider about over-thecounter supplements containing anti-oxidants.
- Increase your amount of physical activity as approved by your medical provider.
Sign up
Sign up now and create your account. Use code HEALTH10 for a 10% discount on any plan. Don't miss out!
Organize
Bring all results from any laboratories to your account. You can enter your tests yourself, or we'll be happy to organize your files—whether in PDF, JPEG, CSV, or even screenshots.
Learn and improve
Once your information is stored in your account, dive into a wealth of insights about your results. If you have any more questions, we are here to answer them.
Guiding our user for 10 years to promptly understand, track, and act on their laboratory results.
$15/month
for personal lab results
Cancel your subscription at any time.
$250/once
full premium version
$45/month
track your clients’ labs
Cancel your subscription at any time.
Guiding our user for 10 years to promptly understand, track, and act on their laboratory results.
Personal plans
track personal results
Professional Plan
track multiple client's results
$15/month
for personal lab results
$250/once
own it for life
$45/month
for health professionals
Complete Plan
Unlimited Plan
$15 per month
$250 full version
Are you a health professional?
Level up your lab report analysis with our Pro plan, built for health practitioners like you.
Health Business Account
$45/month
Cancel your subscription at any time.
Unlock additional Pro plans when you sign up.
Unlock Your Health Journey with Healthmatters.io! Ever wished for a one-stop digital health haven for all your lab tests? Look no further! Healthmatters.io is your personalized health dashboard, bringing together test reports from any lab. Say goodbye to scattered results—organize and centralize your lab data effortlessly. Dive into the details of each biomarker and gain insights into the meaning behind your medical test data.
Join the community of thousands who've transformed the way they understand their lab results. Experience the joy of having all your lab data neatly organized, regardless of where or when the tests were done.
For our professional users, Healthmatters.io is a game-changer. Revel in the intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history. It's not just a dashboard; it's your gateway to a smarter, more informed health journey!
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we do talk about popular labs, we welcome reports from lots of other places too. It's as simple as this: if you can get a test done, you can upload it to Healthmatters. We can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
Still on the hunt for a specific biomarker? Just tell us, and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account!
There are two ways to add your test reports to your healthmatters.io account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you. We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.
Depending on your account, the data entry service can be included for free or come at an additional cost of $15 per report.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
The Unlimited plan is a one-time purchase for $250, and it covers your account for a lifetime with no additional payments.
For the Complete plan, the cost is $15 per month. You have the flexibility to cancel it anytime through your account settings, ensuring no further payments. To avoid charges, remember to cancel at least a day before the renewal date. Once canceled, the subscription remains active until the end of the current billing cycle.
Additionally, you can upgrade to the yearly Advanced plan from within your account. The annual cost is $79, and it comes with a data entry service for five reports.
You can always upgrade to a lifetime version with a prorated price from a monthly or yearly subscription.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Unlocking the insights from your lab tests has never been this intuitive! We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into a treasure trove of testing data.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewGet a quick grasp of your test reports in minutes! Explore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Experience the power of clear, organized data visualization with Healthmatters.io — your key to understanding and taking charge of your health journey!
Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional or business account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
%sdLDL-C, Apo B : Apo A-1, ApoA-I, Atherogenic index, Estimated CHD Risk, Fibrinogen, Glycomark (1 ,5-Anhydroglucitol), HDL-C, HDL-C/TG, hsCRP, IDL Cholesterol, LDL-C, LDL/HDL Cholesterol Ratio, Leptin : Adiponectin ratio, Myeloperoxidase (MPO), Non-HDL Cholesterol, Oxidized LDL, Oxidized LDL : LDL-C, OxLDL (Oxidized LDL), PLAC, PLAC (LP-PLA2 Activity), Small dense LDL Cholesterol, Small dense LDL-C : LDL-C, Total Cholesterol, Total Cholesterol/HDL Ratio, Triglycerides, Triglycerides to HDL Ratio, VLDL-C/TG, VLDL-C/TG (Boston Heart)
