Leptin : Adiponectin ratio

Optimal Result: 1.5 - 3.2 Ratio.

Adipokines, hormones produced by fat cells, are regulators of insulin sensitivity, inflammation, oxidative stress and hepatic fatty acid oxidation and secretion of plasma triglycerides. With increased adiposity the level of adiponectin declines. Low levels of adiponectin are associated with marked increases in risk for developing metabolic syndrome, type II diabetes and coronary artery disease. In contrast levels of leptin increase due to leptin resistance that is associated with loss of appetite regulation (satiety).

A high of leptin to adiponectin ratio (LAR) is associated with diminished anti-inflammatory, anti-atherogenic, anti-diabetic, anti-oxidative properties, and endothelial dysfunction. There is increased concern with respect to CVD when a high LAR is concomitant with elevated hsCRP (3-10 mg/L).

 

What does it mean if your Leptin : Adiponectin ratio result is too low?

The ratio of leptin to adiponectin has been evaluated as a biomarker for a variety of health conditions. As with any ratio, it is important to examine the levels of the individual analytes to determine which of the two is out of line. Approximately 10% of obese patients may have low leptin levels; this may reflect an inherited leptin deficiency.

What does it mean if your Leptin : Adiponectin ratio result is too high?

A high of leptin to adiponectin ratio (LAR) is associated with diminished anti-inflammatory, anti-atherogenic, anti-diabetic, anti-oxidative properties, and endothelial dysfunction. There is increased concern with respect to CVD when a high LAR is concomitant with elevated hsCRP (3-10 mg/L).

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