Glycomark (1 ,5-Anhydroglucitol)

Optimal Result: 6.8 - 29 ug/ml.

Glycomark (1,5-anhydroglucitol) –indicates poor control of blood glucose spikes; specifically frequent hyperglycemic events over the past two weeks (not evidentfrom HbA1c). Postprandial hyperglycemia is associated with Cardiovascular disease and reduction of hyperglycemic events appear to decrease macro- and microvascular complications in diabetic patients. Low 1,5-AG is also associated with renal damage. Hemoglobin A1c (HbA1c) – estimates the average blood glucose concentration for the life of the red blood cell (120 days).

- Detects recent hyperglycemia and hyperglycemic excursions.

- Reveals improving or worsening glycemic control for the prior one to two weeks.

- Is independently associated with increased rates of diabetes complications.

- Identifies patients that may benefit from closer diabetes management. Is a non-fasting, FDA cleared blood test that complements A1C.

References:

Lee AK, Lee CJ, Huang ES, Sharrett AR, Coresh J, Selvin E. Risk Factors for Severe Hypoglycemia in Black and White Adults With Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study. Diabetes Care. 2017 Dec;40(12):1661-1667. doi: 10.2337/dc17-0819. Epub 2017 Sep 19. PMID: 28928117; PMCID: PMC5711330.

Rawlings AM, Sharrett AR, Mosley TH, Ballew SH, Deal JA, Selvin E. Glucose Peaks and the Risk of Dementia and 20-Year Cognitive Decline. Diabetes Care. 2017 Jul;40(7):879-886. doi: 10.2337/dc16-2203. Epub 2017 May 12. PMID: 28500217; PMCID: PMC5481977.

Kim YG, Hahn S, Oh TJ, Kwak SH, Park KS, Cho YM. Differences in the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors between Asians and non-Asians: a systematic review and meta-analysis. Diabetologia. 2013 Apr;56(4):696-708. doi: 10.1007/s00125-012-2827-3. Epub 2013 Jan 24. PMID: 23344728.

Monnier L, Lapinski H, Colette C. Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c). Diabetes Care. 2003 Mar;26(3):881-5. doi: 10.2337/diacare.26.3.881. PMID: 12610053.

What does it mean if your Glycomark (1 ,5-Anhydroglucitol) result is too high?

ABNORMAL results indicate significant hyperglycemia and/or glycemic variability occurring in the fasting state, post-meal state, or both during the prior two weeks. ABNORMAL GlycoMark test results are independently associated with an increased risk of diabetes related complications.

- Consistent with significant recent hyperglycemia/glycemic variability.

- Consider fasting glucose, structured SMBG (Self-monitoring blood glucose) and/or CGM (Continuous Glucose Monitoring) to determine hyperglycemic patterns.

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