LCA and DCA are secondary bile acids.
What are bile acids?
Bile acids are the final product of cholesterol metabolism in the liver. They play an important role in fat digestion and absorption. The primary bile acids are chenodeoxycholic acid (CDCA) and cholic acid (CA).
These bile acids can be converted into secondary bile acids in the colon.
CDCA is converted into lithocholic acid (LCA) and CA is converted into deoxycholic acid (DCA).
What are secondary bile acids?
These secondary bile acids are associated with disease. An LCA:DCA ratio greater than 1 is associated with increased risk of gallstones, breast cancer, and colorectal cancer.
Colonic bacteria metabolize primary bile acids to secondary bile acids. Dietary fiber and bacteria flora determine the rates of metabolism for the secondary bile acids, lithocholic acid (LCA) and deoxycholic acid (DCA).
The LCA:DCA ratio may be an important discriminating marker in colorectal cancer susceptibility. An elevated secondary bile acid ratio is associated with an increased risk of breast and colorectal cancer. Elevated levels may also occur in patients with gall stones and after cholecystectomy.
- Steroids and cancer: faecal bile acid screening for early detection of cancer risk. - [L]
- Rye Bread Improves Bowel Function and Decreases the Concentrations of Some Compounds That Are Putative Colon Cancer Risk Markers in Middle-Aged Women and Men [L]
- Fecal steroids and colorectal cancer. [L]
- A prospective study of serum bile acid concentrations and colorectal cancer risk in post-menopausal women on the island of Guernsey [L]
Low levels are generally not a concern as a lower LCA/DCA ratio may indicate a reduced risk of colon cancer.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
An LCA:DCA ratio greater than 1 is associated with increased risk of gallstones, breast cancer, and colorectal cancer.
A diet high in fibre and/or fibre supplementation can help return bile acid results to normal as it absorbs cholesterol and reduces the overall concentrations of secondary bile acids. Probiotic supplements have also been shown to reduce the conversion of primary bile acids to toxic secondary bile acids. A study has shown that the normal consumption of whole-meal rye bread as part of a habitual diet has favorable effects in the colon in terms of colon cancer risk.
Interpret Your Lab Results
Upload your lab report and we’ll interpret and provide you with recomendations today.Get Started
Get Started With Our Personal Plan
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
for health professionals
$45 per month
Astrovirus, Beneficial SCFAs, Bilfidobacterium, Chymotrypsin, Deoxycholic acid (DCA), Enteroaggregative E. coli (EAEC), Enteropathogenic E. coli (EPEC), Enterotoxigenic E. coli (ETEC) It/st, Escherichia coli, Fluoroquinolones, Lactobacillus species, LCA / DCA Ratio, Lithocholic acid (LCA), M2 Pyruvate Kinase, Mycobacterium tuberculosis (avium), Plesiomonas shigelloides, Prevotella copri, Putrefactive SCFAs, Rotavirus, Stool pH, Vibrio (parahaemolyticus, vulnificus and cholerae)