Prevotella copri is a gut bacteria that may cause rheumatoid arthritis. Studies consistently find different bacterial patterns in people with inflammatory arthritis vs controls. Some of those are high in prevotella copri.
The studies show that in control groups a large percentage (75%) of patients that have RA, but hadn't yet been treated, have Prevotella copri present in their intestines. In another group of patients, with either rheumatoid or psoriatic arthritis, 37% of patients show Prevotella copri and only 21% in healthy controls.
High levels of Prevotella copri and similar species are correlated with low levels of microbiota previously associated with immune regulating properties. In addition, some nutrients can alter intestinal permeability and thereby influence the immune response without a known impact on the microbiota. However, critical questions remain to be elucidated, such as the way microbiome fluctuates in relation to diet, and how disease activity may be influenced by changes in diet, microbiota or diet-intestinal microbiota equilibrium. [L]
Dillon et al. [L] suggested that increased levels of P. copri might contribute to driving chronic inflammation in individuals infected with HIV. Furthermore, Lukens et al. [L] demonstrated gut dysbiosis with abundance of Prevotella in a mouse model of osteomyelitis.
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