Stool

M2 Pyruvate Kinase

Optimal Result: 0 - 4 U/mL.

The majority of human tumours strongly over-express the tumour M2 isoform of the glycolytic enzyme Pyruvate Kinase
(M2-PK), which is released from tumour cells and is quantitatively detectable in body fluids. M2-PK is the key regulator of tumour
metabolism and its measurement in faeces identifies gastrointestinaltumours, even in the absence of gastrointestinal bleeding.

What does it mean if your M2 Pyruvate Kinase result is too high?

- M2-PK values greater than 4 U/mL may indicate gastrointestinal adenoma, colorectal cancer or other gastrointestinal carcinomas.

- Tumor M2-PK has a higher sensitivity than markers CEA and CA72-4, and M2-PK values greater than 4 U/mL may indicate gastrointestinal adenoma, colorectal cancer or other gastrointestinal carcinomas.

- M2-PK has a lower sensitivity and specificity in diagnosing pancreatic cancer compared to Ca 19-9. However, in patients with adenocarcinoma there is a simultaneous increase of M2-PK and Ca 19-9. In addition, M2-PK is more commonly elevated in metastatic disease and may be an additional criterium to decide on radical surgery of pancreatic cancer.

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