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Reference range: Negative, Positive
The evaluation of patients with suspected systemic rheumatic disease, especially systemic lupus erythematosus (SLE).
Reference range: <or=4 IU/mL: Negative, 5 - 9 IU/mL: Indeterminate, >or=10 IU/mL: Positive
Useful to evaluate patients with signs and symptoms consistent with lupus erythematosus (SLE).
Of the systemic lupus erythematosus (SLE)-specific antibodies the antibodies to double-stranded DNA (dsDNA) is the most common.
Testing for IgG antibodies to dsDNA is indicated in patients positive for anti-cellular antibody (ie, antinuclear antibody: ANA) homogeneous pattern using HEp-2 substrate by indirect immunofluorescence assay (IFA) along with clinical features compatible with SLE.
Optimal range: 0 - 2 µmol/L
Docosadienoic acid is an omega-6 fatty acid. Omega-6 fatty acids are a type of polyunsaturated fat found in vegetable oils, nuts and seeds.
Optimal range: 2.1 - 10 wt %
Docosahexaenoic acid (DHA) is one of the omega-3 fatty acids.
Optimal range: 0.8 - 5 wt %
Docosahexaenoic acid (DHA) is an omega-3 fatty acid with 22 carbons and 6 double bonds (22:6n3). It can be obtained from the diet, supplemented, or created by conversion from DPA using elongase and desaturase enzymes. DHA is present in fatty fish such as salmon, tuna, and mackerel, and low levels of DHA can be found in meat and eggs. Both individually or in combination with EPA, DHA is widely supplemented due to the enormous amount of research available regarding its anti-inflammatory role in many clinical conditions such as cardiovascular disease, cognitive decline, autoimmune disease, fetal development, visual disturbances, cancer, and metabolic syndrome.
Optimal range: 31 - 213 µmol/L
Docosahexaenoic acid (DHA) is one of the omega-3 fatty acids.
Optimal range: 1 - 6.5 %
Docosahexaenoic acid (DHA) is an omega-3 fatty acid with 22 carbons and 6 double bonds (22:6n3). It can be obtained from the diet, supplemented, or created by conversion from DPA using elongase and desaturase enzymes. DHA is present in fatty fish such as salmon, tuna, and mackerel, and low levels of DHA can be found in meat and eggs. Both individually or in combination with EPA, DHA is widely supplemented due to the enormous amount of research available regarding its anti-inflammatory role in many clinical conditions such as cardiovascular disease, cognitive decline, autoimmune disease, fetal development, visual disturbances, cancer, and metabolic syndrome.
Optimal range: 1.14 - 3 wt %
Docosapentaenoic acid, or DPA, is a lesser known member of the omega-3 family.
Optimal range: 0.34 - 5 wt %
Docosapentaenoic acid (DPA) is an omega-3 fatty acid with 22 carbons and five double bonds (22:5n3). It is formed from its precursor, EPA, by way of the elongase enzyme which adds two carbons. It can be supplemented or obtained in the diet from foods such as marine oily fish.
Not only is DPA found in most fish and marine foods but it is also present in lean red meat from ruminant animals.
Optimal range: 11 - 50 µmol/L
Docosapentaenoic acid, or DPA, is a lesser known member of the omega-3 family.
Optimal range: 0.08 - 0.83 %
Docosapentaenoic acid (DPA) is an omega-3 fatty acid with 22 carbons and five double bonds (22:5n3). It is formed from its precursor, EPA, by way of the elongase enzyme which adds two carbons. It can be supplemented or obtained in the diet from foods such as marine oily fish.
Not only is DPA found in most fish and marine foods but it is also present in lean red meat from ruminant animals.
Optimal range: 0.53 - 2.81 %
Docosapentaenoic acid (DPA) is an omega-3 fatty acid with 22 carbons and five double bonds (22:5n3). It is formed from its precursor, EPA, by way of the elongase enzyme which adds two carbons. It can be supplemented or obtained in the diet from foods such as marine oily fish.
Not only is DPA found in most fish and marine foods but it is also present in lean red meat from ruminant animals.
Optimal range: 1.5 - 4.2 wt %
Docosatetraenoic acid is also known as Adrenic acid / Adrenate.
Docosatetraenoic acid is a member of the class of compounds known as very long-chain fatty acids.
Fatty acids belong to one of three types or families: saturated, monounsaturated and polyunsaturated. These names describe the structure of the fatty acid in terms of whether it is fully loaded with hydrogen.
Optimal range: 0.45 - 1.25 wt %
Docosatetraenoic acid (DTA) is a very long chain omega-6 fatty acid with 22 carbons and 4 double bonds (22:4n6).
It is synthesized by adding 2 carbons atoms to the backbone of arachidonic acid using the elongase enzyme. It is sometimes referred to by its common name adrenic acid and is one of the most abundant fatty acids in the early human brain and the adrenal gland. DTA has not been well studied, though it has recently been shown to have important physiologic functions. It is now believed to be a pro-resolving mediator in inflammation by blocking neutrophilic metabolites and dampening the inflammation response. For example, in osteoarthritis DTA enhances phagocytosis by macrophages which clears products of cartilage breakdown in the joint space. Supplementation of DTA is being studied as a promising intervention in osteoarthritis to dampen inflammation and prevent structural damage.
Optimal range: 2.6 - 18.1 µmol/L
Docosatetraenoic acid is also known as Adrenic acid / Adrenate.
Docosatetraenoic acid is a member of the class of compounds known as very long-chain fatty acids.
Fatty acids belong to one of three types or families: saturated, monounsaturated and polyunsaturated. These names describe the structure of the fatty acid in terms of whether it is fully loaded with hydrogen.
Optimal range: 0.3 - 2.5 %
Docosatetraenoic acid is also known as Adrenic acid / Adrenate.
Docosatetraenoic acid is a member of the class of compounds known as very long-chain fatty acids.
Fatty acids belong to one of three types or families: saturated, monounsaturated and polyunsaturated. These names describe the structure of the fatty acid in terms of whether it is fully loaded with hydrogen.
Optimal range: 0 - 0 mmol/mol creatinine
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