Mosaic Diagnostics

The Comprehensive Stool Analysis detects the presence of pathogenic microorganisms such as yeast, parasites, and bacteria that contribute to chronic illness and neurological dysfunction. It provides helpful information about prescription and natural products effective against specific strains detected in the sample. The test also evaluates beneficial bacteria levels, intestinal immune function, overall intestinal health, and inflammation markers. Many chronic disorders come from digestive problems and inadequate nutrient absorption. Proper gastrointestinal function is needed to eliminate toxic substances, pathogenic microbes, and undigested food particles from the body to prevent health problems. Nutrients require a specific internal environment to be properly digested and transported throughout the body. Abnormal intestinal microorganisms in the GI tract are widely known to cause disease. Research shows a relationship between the GI tract and the neurological, hepatic, and immune systems. For example, excessive yeast produces toxic substances that can pass through the blood-brain barrier and alter neurological functioning causing “brain fog,” behavior problems, and learning difficulties. Why Conduct a Comprehensive Stool Analysis? The Comprehensive Stool Analysis + Parasitology (CSAP) is an essential diagnostic tool that enables practitioners to assess the status of beneficial and imbalanced commensal bacteria, pathogenic bacteria, yeast/fungus, and parasites. The identification of pathogenic species and susceptibility testing assists in the selection of the most suitable pharmaceutical or natural treatment agents. The Comprehensive Stool Analysis test measures: Digestion and absorption of nutrients (Pancreatic Elastase, Muscle Fibers, and Vegetable Fibers) Elimination efficiency of undigested food residues and toxins Assessment of the gut microbiome, measuring levels of healthy bacterial flora versus potentially pathogenic bacteria species, yeast, and parasites Culture and sensitivities of pathogenic yeast and bacteria Infectious pathogens (EIA evaluation for Campylobacter, Enterohemorrhagic E. coli cytotoxin, Giardia lamblia, and Cryptosporidium) Indices and markers of intestinal immune function (Secretory IgA) Indices and markers of inflammation (Calprotectin, Lactoferrin, and Lysozyme) Indices and markers of intestinal physiology and of intestinal health (Presence of RBC, WBC, Mucus, Occult Blood, Fecal pH, and Short Chain Fatty Acids) Efficient remediation of GI dysfunctions involves a comprehensive approach that includes elimination of pathogens and irritants, supplementation of hydrochloric acid, pancreatic enzymes, and pre- and probiotics, and repair of the mucosal barrier.

What Is the MycoTOX Profile? The MycoTOX Profile is a specialized urine test designed to detect multiple mycotoxins—harmful chemicals produced by molds found in food and indoor environments. Common sources include grains, spices, nuts, and areas with water damage, leaks, or humidity issues in homes and workplaces. This test uses creatinine correction to adjust for urine concentration, allowing for more reliable results and easier monitoring over time. Why Test for Mycotoxins? Mycotoxin exposure is a frequent concern worldwide, especially through contaminated foods and poor indoor air quality. While healthy people often clear low-level exposures, recurring or elevated exposure can cause non-specific symptoms, such as fatigue, headaches, sinus congestion, respiratory irritation, or skin problems. Those living or working in moisture-damaged buildings, with asthma, or with environmental sensitivities may face higher risks. Importantly, the MycoTOX Profile identifies exposure—not specific diseases—empowering targeted prevention and remediation. Who Should Consider MycoTOX Testing? Unexplained, ongoing symptoms with potential mold or moisture issues at home or work Diets high in stored grains, nuts, spices, or red yeast rice supplements Monitoring after building mold remediation Environmental illness evaluation in collaboration with a healthcare provider How to Prepare for the Test Follow all lab urine collection and shipping instructions. Maintain regular hydration and avoid excessive drinking or fasting before testing. Inform your clinician of any medications or supplements, especially binders like charcoal or clays, which can alter results. Interpreting Your MycoTOX Results Result Category Interpretation Next Steps Not Detected / Low Minimal recent exposure; normal clearance Maintain current routines; retest only if needed Borderline / Moderate Possible ongoing exposure; tighten food storage and review environment Make changes, then retest in 6–12 weeks Elevated Substantial recent exposure Reduce sources, retest after 6–12 weeks, consult clinician Note: MycoTOX results show exposure, not the exact source or organ harm. Combine them with food/supplement audits and environmental assessments for best outcomes. What to Do If Results Are Elevated Reduce Mycotoxin Exposure from Food and Supplements Buy high-quality brands of grains, cereals, nuts, nut butters, and spices; discard products with musty odors or visible mold. Store dry goods in sealed containers in cool, dry areas; avoid long storage in humid conditions. Carefully select red yeast rice (Monascus) supplements—citrinin contamination is possible. Use trusted brands or pause use until consulting a clinician. Diversify your diet to minimize the risk from repeated exposure. Improve Indoor Air and Surfaces Repair leaks, condensation issues, and maintain indoor humidity around 40–50%. Increase room ventilation; use HEPA vacuums and damp-wipe dusty surfaces. For persistent odors or suspected hidden mold, hire an indoor environmental professional. Large-scale contamination usually requires professional remediation. Supportive Measures (Talk to Your Doctor) Some clinicians recommend binders (like activated charcoal) separately from medications and probiotics; antioxidants (e.g., glutathione) may also be suggested. Evidence for each varies, and the focus should remain on removing sources. Prescription antifungals only treat confirmed fungal infections, not simple mycotoxin exposure. Retesting and Tracking Progress Retest in 6–12 weeks after making dietary and environmental changes or after completing remediation. Use consistent collection methods for every test and track steps taken—this helps correlate interventions to results. Limitations and Medical Guidance MycoTOX testing cannot pinpoint the exact source of mycotoxins or diagnose illnesses. Always interpret results with your healthcare provider and consider other laboratory findings and exposure history. Seek medical attention for severe or worsening symptoms.

Written By: B. Dame Updated On: January 27, 2025 Discover how the Organic Acids Test (OAT) from MosaicDX provides insights into metabolic health, gut dysbiosis, nutrient deficiencies, and chronic health conditions with 76 biomarkers in a single, easy-to-collect urine test. What is the Organic Acids Test (OAT)? The MosaicDX Organic Acids Test (formerly Great Plains Laboratory) is a powerful, non-invasive tool that evaluates 76 organic acids in a single, easy-to-collect urine sample. This test offers unparalleled insight into metabolic health, revealing imbalances in metabolic pathways and identifying nutrient deficiencies that may contribute to chronic health conditions. The OAT test provides crucial data for individuals with neurological disorders, chronic illnesses, or symptoms like fatigue, anxiety, or digestive issues. By analyzing a wide range of metabolic markers, the OAT helps uncover underlying causes of complex symptoms and guides personalized treatment strategies. What Does the Organic Acids Test Measure? The OAT measures over 76 biomarkers through advanced techniques like gas and liquid chromatography coupled with mass spectrometry. These biomarkers fall into several clinically meaningful categories: Intestinal Microbial Overgrowth Markers Detects overgrowth of yeast, Clostridia bacteria, and potential mold exposure. Assesses imbalances in gut microflora, which can impact immune function and cause behavioral issues, fatigue, and digestive problems. Oxalate Metabolites Evaluates oxalate levels linked to dietary intake or production by microorganisms. High oxalate levels are associated with kidney stones, pain, and inflammation. Glycolytic Cycle and Mitochondrial Markers Includes markers from the Krebs Cycle, glycolysis, and amino acid metabolism. Identifies mitochondrial dysfunction, which affects energy production and may contribute to fatigue and chronic illnesses. Neurotransmitter Metabolites Analyzes key neurotransmitter pathways, such as phenylalanine, tyrosine, and tryptophan metabolism. Imbalances may influence mood disorders, anxiety, and depression. Pyrimidine, Ketone, and Fatty Acid Oxidation Markers Highlights issues in mitochondrial energy metabolism and fatty acid utilization. Assesses folate status and cellular turnover. Nutritional Markers Measures levels of essential vitamins, antioxidants, and co-factors. Detects deficiencies even when standard serum tests appear normal. Detoxification Markers Evaluates oxidative stress, glutathione sufficiency, and detoxification pathways, including methylation and transsulfuration. Amino Acid Metabolites Identifies potential nutrient needs or genetic metabolic dysfunction based on elevated markers. Mineral Metabolism Markers Provides insights into dietary phosphate intake and Vitamin D status. Why Take the Organic Acids Test? The OAT is particularly beneficial for individuals experiencing: Neurological disorders (e.g., autism, ADHD, Parkinson’s disease) Chronic fatigue Depression or anxiety Fibromyalgia Digestive disorders like IBS or gut dysbiosis Hormonal imbalances (e.g., insulin resistance, PCOS) Unexplained chronic pain With its ability to detect nutrient deficiencies, mitochondrial dysfunction, and detoxification impairments, the OAT empowers healthcare providers to craft personalized, data-driven treatment plans. How Organic Acids Reflect Metabolic Health Organic acids are natural byproducts of protein, carbohydrate, and fat digestion, which play a critical role in energy production and cellular function. However, an abnormal accumulation of organic acids in the urine may signal: Inherited enzyme deficiencies Nutrient deficiencies (e.g., B vitamins, magnesium) Toxic exposure Drug effects Because vitamins and minerals are essential for enzyme function, increased organic acids can indicate a functional nutrient need at the cellular level—even if bloodwork appears normal. Sample Requirements and Preparation Sample Type: First-morning urine collection after an overnight fast. Preparation: Avoid certain foods and supplements, such as apples, grapes, pears, cranberries, and ribose, 48 hours before the test. Why Choose MosaicDX’s Organic Acids Test? Non-invasive testing: A simple urine sample provides detailed insights. Comprehensive analysis: Evaluates 76 biomarkers to uncover metabolic and nutritional imbalances. Actionable results: Helps guide personalized dietary and supplement recommendations for improved health outcomes. Conditions Addressed by the Organic Acids Test The OAT can help address a variety of conditions, including: Anxiety and mood disorders Autism spectrum disorders (ASD) Fatigue and chronic pain Fibromyalgia and muscle weakness Digestive disorders and gut dysbiosis Hormonal imbalances, including insulin resistance Neurological issues, including Parkinson’s and Alzheimer’s Frequently Asked Questions (FAQs) About the Organic Acids Test (OAT) 1. What is the Organic Acids Test (OAT)? The Organic Acids Test (OAT) is a comprehensive urine test that evaluates 76 metabolic markers to assess your body’s metabolic health, nutrient status, and gut microbiome. It provides insights into energy production, detoxification, neurotransmitter balance, and more. 2. Who should take the Organic Acids Test? The OAT is ideal for individuals experiencing: Chronic fatigue or fibromyalgia Anxiety, depression, or other mood disorders Digestive issues, such as bloating or IBS Neurological disorders like ADHD, autism, or Parkinson’s disease Hormonal imbalances, including insulin resistance or PCOS Unexplained pain or inflammation 3. What does the Organic Acids Test measure? The OAT measures a wide range of markers, including: Gut microbial overgrowth (yeast, bacteria, and mold toxins) Oxalate levels (linked to kidney stones and inflammation) Mitochondrial function (energy production) Neurotransmitter metabolites (dopamine, serotonin, etc.) Detoxification markers (glutathione and oxidative stress) Nutritional markers (vitamins, antioxidants, and co-factors) 4. How is the Organic Acids Test performed? The test requires a first-morning urine sample collected after fasting overnight. Certain foods and supplements, such as apples, grapes, cranberries, ribose, and echinacea, should be avoided 48 hours before collection. 5. How does the OAT detect gut microbial overgrowth? The test identifies specific organic acids produced by yeast, bacteria, or molds in the gut. Elevated levels of these markers can signal microbial overgrowth or dysbiosis, which may cause digestive issues, fatigue, or immune dysfunction. 6. Can the Organic Acids Test detect nutrient deficiencies? Yes. The OAT reveals nutrient deficiencies by identifying elevated levels of specific organic acids that indicate a functional need for vitamins or minerals, such as B vitamins, magnesium, or antioxidants. 7. Is the Organic Acids Test suitable for children? Yes, the OAT is safe for children and can be particularly helpful in identifying metabolic imbalances or gut microbial issues in children with developmental or behavioral conditions, such as autism spectrum disorder (ASD). 8. How long does it take to get results from the OAT? Results are typically available within 1-2 weeks after the lab receives the urine sample. A detailed report categorizes findings into actionable sections for healthcare providers. 9. What are the benefits of the Organic Acids Test over traditional tests? The OAT provides functional insights that traditional blood tests may not detect. It evaluates how well your body’s metabolic pathways are working, uncovering nutrient needs, detoxification issues, and mitochondrial dysfunction even when serum levels appear normal. 10. What conditions can the OAT help address? The Organic Acids Test can provide insights for managing: Fatigue and low energy Depression, anxiety, and mood disorders Digestive imbalances, such as gut dysbiosis Neurological disorders (ADHD, autism, Parkinson’s, etc.) Fibromyalgia and chronic pain Oxalate-related conditions (e.g., kidney stones) 11. Can the results of the Organic Acids Test guide treatment? Yes, the results can guide your healthcare provider in creating a personalized treatment plan, including recommendations for dietary changes, targeted nutrient supplementation, and strategies to address underlying imbalances. 12. Are there any limitations to the Organic Acids Test? While the OAT is highly comprehensive, its findings are best interpreted alongside clinical symptoms and under the guidance of a qualified healthcare provider. The test does not diagnose specific diseases but identifies metabolic imbalances that may contribute to symptoms.