Metanephrine Plasma


A healthy result should fall into the range 0 - 62 pg/mL.

Metanephrine is a metabolite of epinephrine. Normally, the levels of Metanephrine are low in the plasma. However, when there are tumors in the body that originate from neural crest cells called paragangliomas or neuroblastomas, or from pheochromocytomas (an adrenal gland tumor), the levels of Metanephrine rise significantly. When Metanephrine levels are normal, then it’s extremely unlikely that someone has pheochromocytoma or paraganglioma. 

If this test is positive, another type of test should be done, called the fractionated 24-hour urinary metanephrines. 

Normal Ranges for Metanephrine in nmol/L: 

<0.50 nmol/L




Metanephrine Plasma result calculator

insert the value from you Metanephrine Plasma test result.

What does it mean if your Metanephrine Plasma result is too low?

Some specific causes of low Metanephrine may include:

- Metyrosine treatment (This is the treatment for pheochromocytoma.)

What does it mean if your Metanephrine Plasma result is too high?

High levels of Metanephrine can be from a pheochromocytoma. This is usually a benign tumor that stems from aberrant cells in the adrenal gland. The tumor produces hormones that cause high blood pressure. The high blood pressure can cause life-threatening situations, such as a heart attack.

Some specific causes of high Metanephrine may include:

- Monoamine oxidase inhibitors from tyramine-rich foods

- Catecholamine reuptake inhibitor consumption (cocaine and local anesthetics, including lidocaine)

- Anesthetic gasses, especially one called halothane

- Sleep apnea

- Going through the sedative drug withdrawal process from alcohol, valium, opioids, and the high blood pressure drug called Clonidine

However, the elevated levels caused by the above-mentioned items are not that significant. 

Upload Full Test and Learn More

To learn more, visualize and track your test results, create a personal account.

Sign Up, Upload Tests, Get Insights and Improve with

Sign up now.

Are you concerned about your blood test results?
Then get your personal health dashboard.


Personal Plan +

Unlimited Tests Upload Subscription
Cancel anytime

Sign Up


Personal Plan Basic

Single test upload.
Pay for each test result upload.

Upload Now

Your Privacy And Security

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put security measures in place to help protect against the loss, misuse or alteration of information under our control. We use procedural, physical and electronic security methods designed to prevent people who aren't authorized from getting access to this information. Our internal code of conduct adds additional privacy protection. See our Privacy Policy for more information.