1-Methylhistidine

Optimal Result: 0 - 3.85 Units.

1-methylhistidine is derived from the dipeptide anserine (which consists of the amino acids 1-methylhistidine and beta-alanine). Anserine and its derivatives are associated with the consumption of poultry and fish. Both 1-methylhistidine and 3-methylhistidine have been proposed as markers of meat intake. Note that confusion exists in the literature regarding the numbering of atoms in the imidazole ring of histidine – 1 versus 3 – and thus, there is caution with interpretation and clinical significance of these two markers.

What does it mean if your 1-Methylhistidine result is too low?

1-Methylhistidine is decreased with low animal protein intake, as seen in vegetarian and vegan diets.

What does it mean if your 1-Methylhistidine result is too high?

Urine and plasma levels of 1-methylhistidine are higher with poultry and fish consumption. Since it is a dipeptide, elevations might also signify incomplete protein digestion.

10 000+ happy customers
100% satisfaction
★ ★ ★ ★ ★ customer support

Trust us to examine your lab results, guiding you towards improved health.

Use promo code to save 10% off any plan.


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.