Phosphoserine is the phosphorylated ester of the amino acid serine. The addition of a phosphoryl group to an amino acid, or its removal, plays a role in cell signaling and metabolism. Phosphoserine is a byproduct of glycolysis and subsequent intermediate to then become serine. The enzyme that catalyzes this step, phosphoserine phosphatase, is magnesium dependent.
This metabolite is not to be confused with a similar-sounding metabolite, phosphatidylserine; this is a common CNS supplement and essential for neuronal cell membranes.
The enzyme which connects glycolysis to the formation of phosphoserine (phosphoserine aminotransferase) requires vitamin B6 as a cofactor. Lack of vitamin B6 can result in lower phosphoserine levels.
Supplementation with vitamin B6 was shown to alter plasma amino acids resulting in increased phosphoserine.
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Elevated phosphoserine may be due to a functional lack of magnesium needed to catalyze the enzymatic conversion of phosphoserine to serine.
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1-Methylhistidine, 3-Methylhistidine, a-Amino-N-butyric Acid, a-Aminoadipic Acid, Alanine, Arginine, Asparagine, Aspartic Acid, b-Alanine, b-Aminoisobutyric Acid, Citrulline, Cyst(e)ine, Cystathionine, Ethanolamine, g-Aminobutyric Acid, Glutamic Acid, Glutamine, Glycine, Histidine, Isoleucine, Leucine, Lysine, Methionine, Ornithine, Phenylalanine, Phosphoethanolamine, Phosphoserine, Proline, Sarcosine, Serine, Taurine, Threonine, Tryptophan, Tyrosine, Urea, Valine
