NutrEval Plasma - Urine and Blood

Valine

Optimal Result: 18.3 - 42.6 Units.

Branched Chain Amino Acids (Isoleucine, Leucine, Valine) Isoleucine, leucine and valine are the three branched chain amino acids (BCAAs).

Branched chain amino acids (BCAA) are essential amino acids and must be obtained from the diet (mainly meat, grains, and dairy). 

Not only do the BCAAs account for almost 50% of muscle protein, but they have many metabolic functions. 

BCAAs act as substrates for protein synthesis, energy production, neurotransmitter production, glucose metabolism, and the immune response. They are also involved in stimulation of albumin and glycogen synthesis, improvement of insulin resistance, inhibition of free radical production, and hepatocyte apoptosis with liver regeneration.

Unlike most amino acids, the initial step of BCAA metabolism does not take place in the liver. After dietary intake, BCAAs remain in circulation and are taken up by skeletal muscle, the heart, kidney, diaphragm, and adipose tissue for immediate metabolism.

BCAAs are transaminated into a-keto acids and used within the tissues or released into circulation.

The liver and other organs can then further catabolize these a-keto acids. 

The complete oxidation of valine yields succinyl CoA, and leucine and isoleucine produce acetyl CoA for use in the citric acid cycle.

Isoleucine also produces propionyl CoA and succinyl CoA. Skeletal muscle is a major site of BCAA utilization.

During exercise, catabolism of the BCAAs is elevated; β-aminoisobutyric acid (β-AIB) is a metabolite of valine released during exercise which is evaluated in the B-Vitamin Marker section below. 

There is much published literature on the use of BCAAs for muscle protein synthesis, however it’s been shown that BCAA supplementation alone does not enhance muscle protein synthesis better than the consumption of a complete, high quality food protein containing the full spectrum of essential amino acids.

What does it mean if your Valine result is too low?

Low levels of essential BCAA may indicate a poor-quality diet, or maldigestion due to deficient digestive peptidase activity or pancreatic dysfunction. 

Low levels of leucine can be seen after significant aerobic exercise or strength training. 

Supplementation with zinc, vitamin B3, and vitamin B6, has improved outcomes in various conditions where low levels of BCAA’s have been associated.

What does it mean if your Valine result is too high?

High protein intake may elevate BCAAs. In the catabolism of BCAAs, branched chain aminotransferase and branched chain alpha ketoacid dehydrogenase complex (BCKDC) require several cofactors such as vitamin B6, vitamin B1, and lipoic acid. Therefore, functional need for these cofactors may contribute to high levels of BCAAs.

Lastly, BCAAs can be elevated due to a rare inborn error of metabolism. Maple Syrup Urine Disease is an inherited disorder of branched chain amino acid metabolism due to deficiency of the BCKDC complex.

10 000+ happy clients
100% satisfaction
★ ★ ★ ★ ★ customer support

Understand blood, stool, and urine medical results from all your laboratories.

Get Started With Our Personal Plan

Advanced Plan

  • ✓ Yearly subscription
  • ✓ Five free uploads
  • ✓ Cancel anytime
  • ✓ Instant interpretations
  • ✓ Use the free self-upload form
  • ✓ 3000+ biomarkers explained
  • ✓ Nutrition Recommendations
  • ✓ Dedicated support
  • ✓ Yearly subscription
  • ✓ Five free uploads
  • ✓ Cancel anytime
$79 per year
  • ✓ Instant interpretations
  • ✓ Use the free self-upload form
  • ✓ 3000+ biomarkers explained
  • ✓ Nutrition Recommendations
  • ✓ Dedicated support

Unlimited Plan

  • ✓ No subscription
  • ✓ Ten free uploads
  • ✓ Unlimited access
  • ✓ Instant interpretations
  • ✓ Use the free self-upload form
  • ✓ 3000+ biomarkers explained
  • ✓ Nutrition Recommendations
  • ✓ Dedicated support
  • ✓ No subscription
  • ✓ Ten free uploads
  • ✓ Unlimited access
$250 full version

Are You a Health Professional?

Get started with our professional plan

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more

Pro Plan

for health professionals

  • ✓ Track multiple clients results
  • ✓ No setup fees
  • ✓ No hidden costs
  • ✓ Cancel anytime
  • ✓ Instant interpretations
  • ✓ Use the free template forms
  • ✓ 3000+ biomarkers explained
  • ✓ Additional team member $25
  • ✓ Personal training and support

$45 per month

Use promo code to save 10% off any plan.


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

×

Understand Your Lab Result Now

  • Instant interpretation
  • 3000+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode: