Optimal Result: 0 - 1.1 micromol/g creatinine.

Sarcosine is also known as N-methylglycine. It is an intermediate and byproduct in the glycine synthesis and degradation. Sarcosine is metabolized to glycine by the enzyme sarcosine dehydrogenase, while glycine-N-methyl transferase generates sarcosine from glycine. It is an intermediate and byproduct in the glycine synthesis and degradation. Sarcosine is metabolized to glycine by the enzyme sarcosine dehydrogenase, while glycine-N-methyl transferase generates sarcosine from glycine. Sarcosine is a natural amino acid found in muscles and other body tissues. Sarcosine is found naturally as an intermediate in the metabolism of choline to glycine. Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1), an N-methyl-D-aspartate receptor (NMDAR) co-agonist, and an important intermediate in one-carbon metabolism.

- Its therapeutic potential for schizophrenia further underscores its clinical importance.

- It is currently also being researched as a biomarker for prostate cancer [1234].

What does it mean if your Sarcosine (Urine) result is too high?

Sarcosine, or N-methylglycine, is an intermediate of the choline-to-serine catabolism sequence. It is formed by oxidative demethylation of dimethylglycine and it is then catabolized by further demethylation.

If Sarcosine is elevated in urine it suggests three possibilities.

1. Recent dietary supplementation of dimethylglycine, "DMG".

2. Deficiencies of the cofactors associated with sarcosine catabolism. These are folic acid as tetrahydrofolate, THF, and Vitamin B2, riboflavin, bound to the sarcosine dehydrogenase enzyme as FAD. The methyl group fragment removed from sarcosine is at the oxidative level of CHO and can form formaldehyde if tetrahydrofolate is insufficient. This would slow down sarcosine's catabolism while making it somewhat toxic.

3. Genetic weakness in sarcosine dehydrogenase with metabolic hypersarcosinuria and possibly hypersarcosinemia. Hereditary (severe) hypersarcosinuria is rare with an incidence of less than 1 in 40,000 newborns.

Unpublished clinical observations associate some cases of acquired, mild sarcosinuria (below 500 micromoles/24 hour) with past exposures to organic chemical solvent and petrochemicals. At such levels sarcosine itself is not known to be toxic. However, folic acid supplementation is suggested whenever sarcosine is elevated.

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Understand blood, stool, and urine medical results from your labs.

Get 10% off your plan.

Use promocode

Advanced Plan personal plan


  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium personal plan


  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Pro Plan for health professionals


  • Track multiple clients results
  • No setup fees
  • No hidden costs
  • Cancel anytime
  • Instant interpretations
  • Use the free template forms
  • 2500+ biomarkers explained
  • Additional team member $25
  • Personal training and support

Healthmatters.io software for professional use.

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.

Learn More


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals
×

Understand Your Lab Result Now

  • Instant interpretation
  • 2500+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode:

;