Norepinephrine (pooled)

Elevated norepinephrine activity seems to be a contributor to anxiousness. Also, brain norepinephrine turnover is increased in conditions of stress. Interestingly, benzodiazepines, the primary anxiolytic drugs, decrease firing of norepinephrine neurons. This may also help explain the reasoning for benzodiazepine use to induce sleep.

High levels are associated with aggression, anxiety, emotional lability, hyperactivity, mania, stress and suppression of the immune system.

In addition high levels of norepinephrine can be related to:

- Stress

- Hyperactivity

- High blood pressure

- ADD

- Anxiety and depression

- Bipolar disorder

- Hyperglycemia

- Hyperinsulemia

- Obesity

- Obstructive sleep apnea

- PTSD

- Stress

Low levels of Norepinephrine contribute to a decrease in mood, energy, focus, motivation and memory.

Norepinephrine functions both as a neurotransmitter and a hormone, participating in the body’s fight or flight response. Norepinephrine increases alertness, focuses attention, fine-tunes vigilance, increases blood pressure, heart rate, and blood glucose, reduces digestive activity, pain and sleep, prevents bladder emptying, and regulates body temperature. The adrenal gland produces approximately 20% of norepinephrine with 80% produced by the sympathetic nerve fibers. Research shows that urinary norepinephrine is reduced in patients with Alzheimer’s disease.

Clinically, low norepinephrine is implicated in anorexia, attention impairment, depression, fatigue, hypotension, lack of motivation, lethargy, low mood, memory issues, slow pulse rate, and weight issues.

In addition low levels of norepinephrine can be related to:

- Lack of energy

- Lack of focus

- Lack of motivation

- Attention impairment

- Depression

- Fatigue

- Hypotension

- Low mood

Can also be seen in:

- Alzheimer’s disease

- Anorexia

Possible treatment:

If norepinephrine is low, precursor supplementation with tyrosine or phenylalanine, or cofactor support with ascorbic acid, iron, tetrahydrofolic acid, and vitamin B6 may be beneficial. Consult your doctor before starting any supplementation.

Norepinephrine, also known as noradrenaline, is important for mental focus and emotional stability.

Norepinephrine functions as a neurotransmitter and hormone that regulates the “fight or flight” response and elevates blood pressure and heart rate, stimulates wakefulness, and reduces digestive activity.