Glycine plays an important role in the body’s ability to detoxify itself as well as in wound healing. It is also important in the creation of nucleic acids and bile acids.
Glycine is one of the non-essential amino acids and is used to help create muscle tissue and convert glucose into energy. It is also essential to maintaining healthy central nervous and digestive systems. Glycine is used in the body to help construct normal DNA and RNA strands. Without glycine the body would not be able to repair damaged tissues; the skin would become slack as it succumbed to UV rays, oxidation, and free radical damage, and wounds would not heal.
Glycine is considered a glucogenic amino acid, which means it helps supply the body with glucose needed for energy. It helps regulate blood sugar levels, and thus glycine supplementation may be useful for treating symptoms characterized by low energy and fatigue, such as hypoglycemia, anaemia, and Chronic Fatigue Syndrome (CFS).
Glycine encephalopathy (non – ketotic hyperglycinemia), is a rare autosomal recessive inherited metabolic disorder. This disorder is characterized by abnormally high levels of glycine in bodily fluids and tissues.
One role of glycine is to act as a neurotransmitter, which is a chemical messenger that transmits signals in the brain. Glycine encephalopathy is caused by a defect in the glycine cleavage system (GCS), an enzyme complex that normally breaks down glycine in the body. A defect in the GCS enzyme complex causes excess glycine to build up in bodily fluids, tissues, and organs, in particular the brain and cerebrospinal fluid (CSF). Excess glycine in the brain and CSF results in serious medical problems, including encephalopathy, hence the name of the disorder.
Possible generalized tissue loss, glycine being part of the nitrogen pool and important in gluconeogenesis. Supplement glycine.
Supplement vitamin B5, folic acid, and vitamins B6, and B2 for the efficient metabolism of glycine to pyruvic acid for oxidation and for glutathione synthesis or gluconeogenesis.
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