If you can test it, we can track it — all test results, including the ones from your favorite labs.

Optimal Result: 5.2 - 15.3 µg/g creatinine.

Histamine is a compound that affects immune response and physiological function of the digestive tract, and also acts as a neurotransmitter.

What are some functions of Histamine?

Histamine helps control the sleep-wake cycle as well as energy and motivation.

The sleep-wake cycle and other areas:

Histamine is a neurotransmitter involved in the sleep/wake cycle and inflammatory response.

Depending on the receptor histamine activates, a wide array of biological actions can occur. For instance, one receptor helps regulate the sleep/wake cycle whereas another receptor helps regulates norepinephrineserotonin, and acetylcholine release. There are also other receptors that may be activated to induce an inflammatory response, which is commonly associated with the exposure to an allergen.

…within the brain:

Interestingly, histamine containing neurons have been found to have a pacemaker function within the brain. The firing rates of these neurons correlate positively with brain activity levels and display distinct day-night rhythms. Within the posterior region of the hypothalamus, there are a large number of neurons that synthesize and utilize histamine. These neurons provide the stimulation that maintains or modulates activity in many other regions of the brain.

Storage and binding:

Histamine, like the other biogenic amines (serotonin, dopamine, norepinephrine, epinephrine, and PEA) is stored in presynaptic vesicles and is released into the synapse. Also like other amine neurotransmitters, histamine binds to transmembrane G-protein coupled receptors on the post-synaptic neurons to exert its function.

What does it mean if your Histamine result is too low?

Feeling tired

What does it mean if your Histamine result is too high?

Elevated histamine may be associated with allergy-like symptoms, gastro-intestinal concerns, skin itch/inflammation (Pruritis – a common skin disease that makes you want to scratch.), increased wakefulness and insomnia, and has been demonstrated in gastrointestinal blastocystis infections.

Levels may be elevated due to:

- use of histamine-releasing medications

- consumption of allergenic and sulfite-rich foods and/or histamine-rich foods

- dysbiotic bacterial production in the intestine

- zinc deficiency

High urine (and blood) histamine levels have been associated with cluster and cyclic headaches. Break down of histamine requires SAMe and copper.

If you can test it, we can track it — all test results, including the ones from your favorite labs.

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Essential Plan


  • Monthly subscription
  • Instant interpretation
  • Use the free self-upload form
  • Additional charge for upload service
  • 1500+ biomarkers explained
  • Recommendations
  • Cancel anytime

Advanced Plan


  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 1500+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium plan


  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 1500+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals