Amino Acid Profile, Qn, Plasma (LabCorp)

Beta-aminoisobutyrate

Optimal Result: 0 - 4.3 umol/L.

Beta-aminoisobutyric acid (BAIB) is an amino acid end product of the pyrimidine metabolism. It is excreted in small quantities into the urine in almost all human beings. Thymine, released when RNA and DNA are degraded, enters a catabolic pathway that leads to Beta-Aminoisobutyric Acid.

References:

- Beta-aminoisobutyric acid excretion [L]

- beta-Aminoisobutyric acid as a marker of thymine catabolism in malignancy. [L]

What does it mean if your Beta-aminoisobutyrate result is too high?

- High b-Aminoisobutyric Acid in urine is a benign metabolic polymorphism present in some human populations due to deficiency of hepatic BAIB-pyruvate transaminase.

- Over 40% of some asian populations have this condition.

- Excretion of BAIB increases in x-ray radiation-induced destruction of DNA.

- Parenteral administration of excessive folic acid (by injection for example) also stimulates cell turnover that results in increased BAIB.

- If this amino acid is high, it may indicate a vitamin B6 deficiency.

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