Thyroid peroxidase (TPO) is an enzyme that is critical for to thyroid hormone synthesis in the thyroid gland. Thyroid peroxidase (TPO) antibodies bind to and block the action of TPO, resulting in decreases in thyroid hormone levels. The presence of TPO antibodies in the blood is abnormal and usually indicates thyroid disease. The thyroid peroxidase (TPO) antibodies test is usually ordered after thyroid abnormalities have been detected with some other type of testing, such as TSH and free T4. It is usually ordered with thyroglobulin antibody testing.
Normal range for Thyroid Peroxidase Antibodies:
Quest Diagnostics: <9 IU/mL
LabCorp: adults: <34 IU/mL
Other age ranges by LabCorp:
|
Age |
Range (IU/mL) |
|---|---|
|
0 to 6 d |
0−117 |
|
7 d to 3 m |
0−47 |
|
4 to 11 m |
0−32 |
|
1 to 5 y |
0−13 |
|
6 to 10 y |
0−18 |
|
11 to 19 y |
0−26 |
|
>19 y |
0−34 |
The thyroglobulin antibody level cannot be too low.
Thyroid peroxidase (TPO) antibodies are autoantibodies, which means the body mistakenly produces these antibodies that act against a normal protein, TPO. As such, thyroglobulin antibodies usually indicate an autoimmune disease. TPO antibodies are present in roughly 90% of people with Hashimoto's thyroiditis and in half to three-quarters of people with Graves' disease. Thyroglobulin antibodies may be detectable in people without symptoms of thyroid hormone imbalance (subclinical hypothyroidism). When hypothyroidism causes symptoms, it may cause weakness and fatigue, cold intolerance, shortness of breath, weight gain, constipation, cognitive problems, dry skin, hoarseness, and swelling (edema). In about 10% of cases, TPO antibodies will be detectable in non-autoimmune thyroid disease such as pernicious anemia and type 1 diabetes mellitus.
Some specific causes of thyroid peroxidase (TPO) antibodies are:
$79 per year
$6.60 per month billed annually
Use promocode
$79 per year
$250 single payment
$45 per month
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.
Learn More
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
5-Methyltetrahydrofolate, Adiponectin, Albumin/Creatinine Ratio, Random Urine, C-Peptide, Serum, Ceruloplasmin, Cyclic AMP, Plasma, Dihydrotestosterone (female), Dihydrotestosterone (male), Estimated Average Glucose (eAG), Free Androgen Index, Free testosterone, Free Testosterone, Direct (Female), Free Testosterone, Direct (Male), Free Thyroxine, Free Thyroxine Index, Fructosamine, Glucose, Glutamic Acid Decarboxylase, Hemoglobin A1c (HbA1c), Homocysteine, Insulin (Fasting), Insulin-Like Growth Factor I (IGF-1), Iodine, Serum/Plasma, Parathyroid Hormone (PTH), Serum, Pregnenolone, Reverse T3, Serum, Sex Hormone-Binding Globulin (SHBG), T3, Free, T4, Free, T4, Total (Thyroxine), T7 Index, Testosterone, Testosterone (Female/Child), Testosterone, Serum (Female), Thyroglobulin, Thyroglobulin Antibodies, Thyroid Peroxidase Antibodies (Anti-TPO Ab), Thyroid Stim Immunoglobulin, Thyroid-Stimulating Hormone (TSH), Thyrotropin Receptor Ab, Serum, Thyroxine-binding globulin, TBG, Total T3, Tri iodothyronine (T3) Uptake, Triiodothyronine, Serum
