Glutaric Acid is formed from the essential amino acids lysine and tryptophan through the intermediaries of alpha ketoadipic acid and glutaryl-CoA. Glutaryl-CoA is further metabolized to glutaconyl- and crotonyl-CoA by an enzyme called glutaryl-CoA dehydrogenase. This enzyme requires riboflavin (vitamin B2) as a cofactor.
References:
- Beresford MW, Pourfarzam M, Turnbull DM, Davidson JE. So doctor, what exactly is wrong with my muscles? Glutaric aciduria type II presenting in a teenager. Neuromusc Dis 2006;16(4):269- 273.
- Behin A, Acquaviva-Bourdain C, Souvannanorath S, et al. Multiple acyl-CoA dehydrogenase deficiency (MADD) as a cause of lateonset treatable metabolic disease. Rev Neurolog. 2016;172(3):231- 241.
- Chalmers RA, Bain MD, Zschocke J. Riboflavin-responsive glutaryl CoA dehydrogenase deficiency. Mol Genet Metab. 2006;88(1):29- 37.
- Chokchaiwong S, Kuo Y-T, Lin S-H, et al. Coenzyme Q10 serves to couple mitochondrial oxidative phosphorylation and fatty acid β-oxidation, and attenuates NLRP3 inflammasome activation. Free Rad Res. 2018;52(11-12):1445-1455.
Low levels of glutaric acid, which can indicate a deficiency in riboflavin (vitamin B2), have various implications. Riboflavin is an essential nutrient that plays a crucial role in energy metabolism and cellular function. A deficiency in riboflavin can lead to various health issues, including fatigue, skin disorders, and problems with the nervous system. Glutaric acid is used as an indicator in laboratory tests to identify riboflavin deficiency. It's important to address low glutaric acid levels by increasing the intake of foods rich in vitamin B2 or by taking riboflavin supplements as recommended by a healthcare professional. Riboflavin deficiency is treatable and can be managed effectively with dietary adjustments and supplementation.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get your interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
Elevations of urinary glutaric acid may reflect enzymatic insufficiency requiring vitamin B2 or mitochondrial electron transport dysfunction. Deficiencies of the enzyme glutaryl-CoA dehydrogenase, and multiple acyl-CoA dehydrogenase deficiency (MADD), are well-studied inborn errors of metabolism which result in significant glutaric aciduria. However, milder forms of this rare mitochondrial disorder exist and can result in adult-onset presentations. Late-onset forms can present as atypical beta-oxidation disorders with exercise intolerance, muscle weakness, and CNS dysfunction. In these cases, riboflavin, carnitine, and CoQ10 have been used therapeutically.
Interpret Your Lab Results
Upload your lab report, and we'll interpret and provide you with recommendations today.
Get StartedMonthly plan
Annual plan
Own it for life
Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
$15 /month
billed every month
Most popular
Data entry included
$79 /year
$6.60/month billed annually
Data entry included
$250 /once
own it for life
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Monthly Plus
for health professionals
$75 per month
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
% Free Copper, 25 OH VITAMIN D, Activated Vitamin B12, Adipic Acid, ALBUMIN, ALP, ALT, Anion Gap, ANTITHYROGLOBULIN Ab., Apolipoprotein A-1, Apolipoprotein B, Ascorbic Acid (Vit C), AST, beta-Aminoisobutyric Acid, BICARBONATE, BILIRUBIN (TOTAL), Calc Free Testosterone (Vermeulen), CHLORIDE, CHOLESTEROL, Copper/Zinc Ratio, Cortisol (OA), Creatinine, CREATININE (mmol/L), DHEA Sulphate, ESTRADIOL, Ethylmalonic Acid, FERRITIN, FIBRINOGEN, FREE T3, FREE T4, FT3 : Reverse T3 Ratio ( X 100), GGT, GLOBULIN, GLUCOSE (FASTING), Glutaric Acid (Vit B2), Glycine, HDL(Protective), HIGH SEN CRP, Hippurate (OA), HOMOCYSTEINE, Hydroxylysine, Hydroxyproline, Intermediate Density Lipoprotein (IDL-1), Intermediate Density Lipoprotein (IDL-2), Intermediate Density Lipoprotein (IDL-3), Iodine, IRON, LDL Phenotype Pattern, LDL(Atherogenic), LDL/HDL RATIO (Risk Factor), Lipoprotein (a), Low Density Lipoprotein (LDL-1), Low Density Lipoprotein (LDL-2), Low Density Lipoprotein (LDL-3), Low Density Lipoprotein (LDL-4), Low Density Lipoprotein (LDL-5), Low Density Lipoprotein (LDL-6), Low Density Lipoprotein (LDL-7), Mean Particle Size, Mercury, Non-HDL Cholesterol, Omega 3/Omega 6 Ratio, POTASSIUM, PROGESTERONE, PROTEIN - TOTAL, RATIO (APO B / APO A-1), Reverse T3, Selenium, SERUM FOLATE, Sex Hormone Binding Globulin, SODIUM, Suberic Acid, TESTOSTERONE, THYROID PEROXIDASE Ab., Total Omega 9 Fatty Acids, Trans Palmitoleic Acid, TRANSFERRIN, Transferrin Saturation, TRIGLYCERIDES, TSH, TSH RECEPTOR AB, UREA, Very Low Density Lipoprotein (VLDL)