Hydroxylysine is an amino acid related to collagen.
What is collagen?
Collagen is the most abundant protein in your body. It is the major component of connective tissues that make up several body parts, including tendons, ligaments, skin and muscles.
What is lysine?
Lysine is one of nine essential amino acids in humans required for growth and tissue repair. A portion of the lysine of collagen is modified to hydroxylysine, which provides a marker for bone loss due to the turnover of collagen during bone resorption.
What is hydroxyproline?
Collagen metabolism releases a variety of collagen constituents into the circulation. These include amino- and carboxy-terminal extension peptides, pyridinoline, and deoxypyridinoline cross-links, and hydroxyproline.
Hydroxyproline in plasma appears as both peptide bound and free forms. Bone resorption is the major contributor to collagen turnover, and the constituent molecules, including hydroxyproline, are useful as markers of the rate of bone matrix resorption. Hydroxyproline is most useful in conditions associated with markedly increased bone resorption (Paget’s disease, malignancy, hyperparathyroidism).
Both hydroxylysine and hydroxyproline are indicators of liver disease. However, hydroxylysine has the strongest correlation, possibly because dietary intake of collagen can influence hydroxyproline levels.
Changes in hydroxylysine excretion with cadmium loading in experimental animals indicate that cadmium interferes with collagen synthesis.
High plasma levels of Hydroxylysine are indicative of connective tissue breakdown. Collagen is synthesized using the cofactors iron, alpha-ketoglutaric acid and vitamin c.
Supplementation of these nutrients as well as chondroitin sulfate and manganese may be useful in reversing this condition.
Own it for life
Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
billed every month
Data entry included
$6.60/month billed annually
Data entry included
own it for life
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Monthly Plus
for health professionals
$75 per month