Optimal Result: 0.55 - 0.64 Ratio.

This calculated ratio is called the ‘Met/Sulf Balance’ and it compares analytes between the methylation pathway and transsulfuration pathways.

Biomarker levels are compared proportionately allowing potential insight into which of the pathways is being favored.

The four analytes from the main methylation pathway that are used in the Met/Sulf Balance are SAM, SAH, methionine, and homocysteine. The four analytes from the transsulfuration pathway are cystathionine, cysteine, taurine, and glutathione.

Methylated Metabolites

- SAM

- SAH

- Methionine

- Homocysteine

Un-Methylated Metabolites

- Cystahionine

- Cysteine

- Taurine

- Gluthatione

There is a relative balance that exists between the methylation and transsulfuration pathways. This balance ensures that adequate levels of glutathione are produced to counteract oxidative stress and that an adequate amount of SAM is made for methylation reactions.

As with the Methylation Balance ratio, the Met/Sulf balance is a novel biochemical pathway analysis. Early Genova data analysis of this biomarker has demonstrated its ability to distinguish a healthy cohort from an unqualified cohort.

In the presence of increased oxidative stress, more homocysteine is used for glutathione production because oxidative stress induces enzymes in the transsulfuration pathway. Also, transsulfuration is induced by higher levels of intracellular SAM. Therefore, poor methylation status (Methylation Balance Ratio and SAM/ SAH Ratio) may be a risk for low glutathione production. As with the Methylation Balance ratio, the Met/Sulf ratio is based solely on biochemical pathway analysis.

 

LOW

HIGH

SAM/SAH

  • Poor methylation status

  • Consider 5-MTHF, vitamin B12, or SAM-e

  • Consider Mg, Zn support

  • Consider betaine supplementation

  • Consequence of high BMI

  • Consequence of high protein intake • Potentialover-methylation (evaluate supple-mentation)

Methylation Balance Ratio

  • Poor methylation status likely

  • Consider 5-MTHF, B12

  • Consider B6, Mg, iron

  • (With high Met/Sulf) Evaluate oxidative stress and consider antioxidant support

  • Consequence of high BMI

  • Consequence of high protein intake

  • Potentialover-methylation (evaluate supple-mentation)

  • MTR or BHMT SNPs

Met/Sulf Ratio

  • Potential high oxidative stress

  • Ensure adequate methylation status

  • Decrease oxidative stress exposure

  • Consider B6, Mg, iron

  • Consider antioxidant support

  • CBS SNP

  • May be consequence of high SAM/SAH

  • Evaluate oxidative stress and consider antioxidant support

  • Consider glutathione if needed

What does it mean if your Met/Sulf Balance Ratio result is too low?

May be a consequence of high levels of methyl products or potential “over-methylation”.

May be due to adequate methylation status and increased oxidative stress.

- Reduce exposure to oxidative stress – Support with antioxidants

- Potential high oxidative stress

- Ensure adequate methylation status

- Decrease oxidative stress exposure

Look at SAM/SAH ratio and Methylation Balance Ratio as well.

What does it mean if your Met/Sulf Balance Ratio result is too high?

Balanced shifted to Methylation. 

- Look at Methylation Balance and SAM/SAH ratios;

- Consider methylation support to correct low methylation status

- Vitamin B6, especially if high homocysteine (consider adding vitamin B3 if high SAH levels)

- Consider Mg, iron

- Consider antioxidant support

- CBS SNP

- May be consequence of high SAM/SAH

- Evaluate oxidative stress and consider antioxidant support

- Consider glutathione if needed

- Evaluate whether high protein intake or high BMI could be contributing to elevated methylation metabolite

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Understand blood, stool, and urine medical results from your labs.

Get 10% off your plan.

Use promocode

Advanced Plan personal plan


  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium personal plan


  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 2500+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Pro Plan for health professionals


  • Track multiple clients results
  • No setup fees
  • No hidden costs
  • Cancel anytime
  • Instant interpretations
  • Use the free template forms
  • 2500+ biomarkers explained
  • Additional team member $25
  • Personal training and support

Healthmatters.io software for professional use.

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.

Learn More


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals
×

Understand Your Lab Result Now

  • Instant interpretation
  • 2500+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode:

;