Optimal Result:
0.55 - 0.64 Ratio.
This calculated ratio is called the ‘Met/Sulf Balance’ and it compares analytes between the methylation pathway and transsulfuration pathways.
Biomarker levels are compared proportionately allowing potential insight into which of the pathways is being favored.
The four analytes from the main methylation pathway that are used in the Met/Sulf Balance are SAM, SAH, methionine, and homocysteine. The four analytes from the transsulfuration pathway are cystathionine, cysteine, taurine, and glutathione.
Methylated Metabolites
- SAM
- SAH
- Methionine
- Homocysteine
Un-Methylated Metabolites
- Cystahionine
- Cysteine
- Taurine
- Gluthatione
There is a relative balance that exists between the methylation and transsulfuration pathways. This balance ensures that adequate levels of glutathione are produced to counteract oxidative stress and that an adequate amount of SAM is made for methylation reactions.
As with the Methylation Balance ratio, the Met/Sulf balance is a novel biochemical pathway analysis. Early Genova data analysis of this biomarker has demonstrated its ability to distinguish a healthy cohort from an unqualified cohort.
In the presence of increased oxidative stress, more homocysteine is used for glutathione production because oxidative stress induces enzymes in the transsulfuration pathway. Also, transsulfuration is induced by higher levels of intracellular SAM. Therefore, poor methylation status (Methylation Balance Ratio and SAM/ SAH Ratio) may be a risk for low glutathione production. As with the Methylation Balance ratio, the Met/Sulf ratio is based solely on biochemical pathway analysis.
|
LOW |
HIGH |
|
|
SAM/SAH |
|
|
|
Methylation Balance Ratio |
|
|
|
Met/Sulf Ratio |
|
|
Lab Results Explained and Tracked
What does it mean if your Met/Sulf Balance Ratio result is too high?
Balanced shifted to Methylation.
- Look at Methylation Balance and SAM/SAH ratios;
- Consider methylation support to correct low methylation status
- Vitamin B6, especially if high homocysteine (consider adding vitamin B3 if high SAH levels)
- Consider Mg, iron
- Consider antioxidant support
- CBS SNP
- May be consequence of high SAM/SAH
- Evaluate oxidative stress and consider antioxidant support
- Consider glutathione if needed
- Evaluate whether high protein intake or high BMI could be contributing to elevated methylation metabolite
All Your Lab Results.
One Simple Dashboard.
Import, Track, and Share Your Lab Results Easily
Import, Track, and Share Your Lab Results
Import lab results from multiple providers, track changes over time, customize your reference ranges, and get clear explanations for each result. Everything is stored securely, exportable in one organized file, and shareable with your doctor—or anyone you choose.
Cancel or upgrade anytime
What does it mean if your Met/Sulf Balance Ratio result is too low?
May be a consequence of high levels of methyl products or potential “over-methylation”.
May be due to adequate methylation status and increased oxidative stress.
- Reduce exposure to oxidative stress – Support with antioxidants
- Potential high oxidative stress
- Ensure adequate methylation status
- Decrease oxidative stress exposure
Look at SAM/SAH ratio and Methylation Balance Ratio as well.
Article Review & Sources
All our content is backed by peer-reviewed studies, academic research, and trusted medical sources. We're committed to accuracy and transparency — see our editorial policy for details.
Laboratories
Bring All Your Lab Results Together — In One Place
We accept reports from any lab, so you can easily collect and organize all your health information in one secure spot.
Pricing Table
Gather Your Lab History — and Finally Make Sense of It
Finally, Your Lab Results Organized and Clear
Personal plans
$79/ year
Advanced Plan
Access your lab reports, explanations, and tracking tools.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 5 reports entered for you
- Cancel or upgrade anytime
$250/ once
Unlimited Account
Pay once, access everything—no monthly fees, no limits.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 10 reports entered for you
- No subscriptions. No extra fees.
$45/ month
Pro Monthly
Designed for professionals managing their clients' lab reports
- Import lab results from any provider
- Track lab results for multiple clients
- Customize reference ranges per client
- Export lab histories and reports
- Begin with first report entered by us
- Cancel or upgrade anytime
About membership
What's included in a Healthmatters membership
Import Lab Results from Any Source
See Your Health Timeline
Understand What Your Results Mean
Visualize Your Results
Data Entry Service for Your Reports
Securely Share With Anyone You Trust
Let Your Lab Results Tell the Full Story
Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.
Bring all your results together to compare, track progress, export your history, and share securely.
What Healthmatters Members Are Saying
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Anthony
Unlimited Plan Member since 2021
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Karin
Advanced Plan Member since 2020
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Paul
Healthmatters Pro Member since 2024
We implement proven measures to keep your data safe.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
