Choline is used for:
- Epigeneticgeneregulation
- Precursortolipoproteins
- Phospholipids
- Acetylcholine
Choline is an essential dietary nutrient found in many foods. Here are some of the sources:
- vegetables, including broccoli, potatoes, and mushrooms
- whole grains, such as quinoa, rice, and whole wheat bread
- nuts and seeds
- proteins, such as beef, soybeans, fish, poultry, and eggs
Choline can be made endogenously, but dietary intake is needed to prevent deficiency. Choline is a critical cell membrane component. It also helps to ensure the structural integrity and signaling functions within the cell. Choline is a precursor for the important neurotransmitter acetylcholine and the membrane phospholipids phosphatidylcholine and sphingomyelin.
In the methylation cycle, choline is oxidized to form betaine, which can then be used as a methyl donor. Because choline and betaine are involved in the re-methylation of homocysteine back to methionine, they form a backup-pathway that is particularly favored in folate deficiency.
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References:
https://pubmed.ncbi.nlm.nih.gov/18716669/
https://pubmed.ncbi.nlm.nih.gov/20446114/
What does it mean if your Choline result is too high?
- Too much dietary intake (i.e. meat, eggs, soybeans, and wheat germ, etc)
- Upregulation of the betaine/choline backup pathway
Elevated choline levels are associated with key components of metabolic syndrome (dysglycemia, dyslipidemia, and BMI). Betaine showed an opposite relationship. This may suggest a disruption of mitochondrial choline oxidation to betaine as part of the mitochondrial dysfunction seen in metabolic syndrome.
Choline is a major lipotrophe, responsible for creating VLDL. Elevated plasma choline is positively associated with:
- Triglycerides
- Glucose
- BMI
- Body fat
- Waist circumference
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