Estriol is the weakest of the three major naturally-occurring estrogens in women.
Estriol is a product of the metabolism of estrone and estradiol. Because of its weak estrogenic activity, estriol is sometimes preferred for intravaginal use as an alternative to systemic estrogen therapy for the treatment of urogenital atrophy in postmenopausal women.
It is also used in anti-aging skin creams as a form of topical estrogen replacement to counteract the effects of age-related estrogen loss on skin. Estriol is the major estrogen found in the maternal circulation during pregnancy; 90% of this circulating estriol is the product of metabolism of DHEA from the fetal adrenals, and so maternal estriol levels are used as an indicator of fetal health.
In non-pregnant women, estriol levels are similar in both pre- and post-menopause and are also similar to levels in men. Salivary estriol has been found to be predictive of increased risk of preterm labor in pregnant women. In nonpregnant women, it is most commonly used for monitoring of levels in women using estriol-containing supplements as part of hormone replacement therapy.
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11-Deoxycortisol, 17OH-Progesterone, 7-keto DHEA, Aldosterone, Allopregnanolone (Oral or Topical Progesterone), Anastrozole, Androstenedione, Corticosterone, Cortisol (evening), Cortisol (morning), Cortisol (night), Cortisol (noon), Cortisone (Morning), DHEA, DHEAS, DHEAS (Age Dependent), DHT, Estradiol (Postmenopausal), Estradiol [Premenopausal (Luteal)], Estriol (Postmeno or Premeno-Follicular or Synthetic HRT), Estriol (Premenopausal Luteal), Estrone (Postmeno Premeno-Follicular or Synthetic HRT), Estrone (Premeno-luteal), Ethinyl Estradiol, Finasteride, Letrozole, Melatonin, Pregnenolone Sulfate, Progesterone (Postmenopausal), Progesterone [Premenopausal (Luteal)], Progesterone [Top, Troche, Vag Pg (10-30mg)], Ratio: DHEA/7keto DHEA, Ratio: Pg/E2, Ratio: Pg/E2 (Saliva LCMS), Testosterone, Testosterone (Age Dependent)
