Anti-CCP Ab, IgG / IgA (RDL)

Serum
Optimal Result: 0 - 20 Units.

Anti-CCP antibodies, or anti-cyclic citrullinated peptide antibodies, are autoantibodies frequently found in the blood of individuals with rheumatoid arthritis (RA). These antibodies target proteins that have been altered by a process called citrullination; this alteration changes the structure of the protein, causing the immune system to recognize them as foreign. The presence of IgG class anti-CCP antibodies is considered highly specific for RA and is a strong indicator of the disease. They are often detected before the onset of clinical symptoms and are associated with a more severe disease course. The measurement of anti-CCP antibodies is now a common diagnostic test for RA and can aid in the prognosis of the disease, as their presence is correlated with joint damage progression.

What does it mean if your Anti-CCP Ab, IgG / IgA (RDL) result is too high?

If anti-CCP antibodies of the IgG class are elevated, it typically suggests a strong likelihood of rheumatoid arthritis (RA). This elevation is considered one of the most specific markers for the diagnosis of RA, even in the early stages of the disease when symptoms might not be pronounced. Additionally, higher levels of these antibodies are associated with more aggressive disease and can predict a greater risk of joint damage and erosion. The presence of elevated anti-CCP IgG antibodies may also influence the treatment strategy, as it suggests that more aggressive treatment may be necessary to manage the disease and prevent long-term disability. Furthermore, these antibodies can appear years before the onset of clinical symptoms, which makes them a valuable tool for early diagnosis and intervention. However, while their presence is strongly associated with RA, they are not exclusive to it and may be elevated in other conditions, albeit less commonly. Therefore, the results are usually considered alongside clinical evaluation and other diagnostic tests.

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