Anti-Cardiolipin Ab, IgG (RDL)

Serum
Optimal Result: 0 - 15 GPL U/mL.

Anti-Cardiolipin antibodies (aCL) of the IgG class are a type of autoantibody directed against cardiolipin, a phospholipid present in cell membranes. These antibodies are significant in the diagnosis and management of autoimmune disorders, particularly in the context of antiphospholipid syndrome (APS).

APS is characterized by thrombosis (blood clots) and pregnancy complications, including recurrent miscarriages. The presence of anti-cardiolipin antibodies, especially the IgG subtype, is one of the laboratory criteria for diagnosing APS. Elevated levels of these antibodies can increase the risk of blood clot formation in veins and arteries, leading to complications like deep vein thrombosis, stroke, or heart attack.

In pregnant women with APS, these antibodies are associated with complications such as preeclampsia, placental insufficiency, and fetal growth restriction. The "RDL" in this context likely refers to the specific laboratory or testing method used for detecting these antibodies. Testing for anti-cardiolipin antibodies is usually done through immunoassays like ELISA. It's important to note that the presence of these antibodies alone is not sufficient for an APS diagnosis; clinical symptoms and other criteria must also be considered. Moreover, anti-cardiolipin antibodies can be transiently elevated in some infections and certain medications, necessitating careful interpretation of test results in the broader clinical context.

What does it mean if your Anti-Cardiolipin Ab, IgG (RDL) result is too high?

Elevated levels of Anti-Cardiolipin antibodies (aCL), particularly the IgG class, are primarily significant in diagnosing and managing antiphospholipid syndrome (APS), an autoimmune disorder characterized by blood clots and pregnancy complications.

High levels of these antibodies increase the risk of thrombotic events like deep vein thrombosis, strokes, and heart attacks. In pregnancy, they are associated with a higher risk of miscarriages, preeclampsia, and other complications. While these antibodies are closely linked to APS, they can also be present in other autoimmune diseases like systemic lupus erythematosus (SLE). Additionally, their levels can be transiently elevated due to infections or certain medications, necessitating a comprehensive clinical evaluation for accurate diagnosis and management.

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