Anti-Cardiolipin Ab, IgM (RDL)

Serum
Optimal Result: 0 - 13 MPL U/mL.

Anti-Cardiolipin antibodies (aCL) of the IgM class are autoantibodies directed against cardiolipin, a specific phospholipid in cell membranes. These antibodies are clinically significant, especially in the context of antiphospholipid syndrome (APS), an autoimmune disorder characterized by an increased tendency for blood clot formation (thrombosis) and complications in pregnancy. The IgM class of aCL is one of the key markers tested for the diagnosis of APS. Elevated levels of IgM anti-cardiolipin antibodies can indicate an increased risk of both arterial and venous thromboses, such as deep vein thrombosis, pulmonary embolism, stroke, and heart attack. In pregnant women, high levels of these antibodies are associated with an increased risk of complications including recurrent miscarriages, preeclampsia, and placental insufficiency. The "RDL" likely refers to a specific laboratory or testing method for these antibodies. Detection is typically conducted through immunoassay techniques like ELISA. It's important to note that while elevated IgM anti-cardiolipin antibodies are significant in diagnosing APS, they are not the sole criterion. APS diagnosis requires a combination of clinical symptoms and laboratory findings. Additionally, these antibodies can be transiently elevated in certain infections or as a result of medication, thus their presence needs to be interpreted in the broader clinical context.

What does it mean if your Anti-Cardiolipin Ab, IgM (RDL) result is too high?

Elevated levels of IgM class Anti-Cardiolipin antibodies (aCL) are significant in diagnosing antiphospholipid syndrome (APS), an autoimmune disorder associated with an increased risk of blood clots and pregnancy complications. High levels of these antibodies indicate a heightened risk of thrombotic events like deep vein thrombosis, pulmonary embolism, strokes, and heart attacks. In pregnant women, they are linked to a higher risk of recurrent miscarriages and preeclampsia. However, the diagnosis of APS should not be based solely on these elevated levels; a comprehensive clinical assessment and other laboratory tests are essential. It's also important to note that these antibodies can be transiently elevated due to conditions like infections or certain medications, making careful interpretation of the test results crucial.

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