5a-Androstanediol is a testosterone metabolite that is more androgenic than b-Androstanediol. It is metabolized via the 5-alpha metabolic pathway (= increased 5α-reductase activity). In contrast, the 5-beta metabolism makes androgens less potent.
Increased 5a-reductase activity may be accompanied by clinical signs of androgenicity (excess facial hair growth, scalp hair loss, acne, irritability, oily skin, prostate issues in men...etc).
It's important to look at this marker and compare it to 5b-Androstanediol. If your 5a-Androstanediol (this marker) and 5a-DHT are increased and 5b-Androstanediol is normal to low then you can do things to lower the preference of your body to move towards that 5-alpha metabolic pathway.
If your overall testosterone is elevated as well, please refer to the main testosterone biomarker as you have to address the overall testosterone level and which pathway (alpha vs. beta) your body is choosing.
Technically, 5a-Androstanediol can also be formed from DHEA metabolites without going through the testosterone pathway, but they generally tend to correlate with testosterone production.
Androgen deficiency can lead to:
- decreased sexual function
- bone loss
If your 5a-Androstanediol and 5a-DHT levels are increased, and your overall testosterone levels are normal (or even high) then your body is leaning towards the more androgenic 5-alpha metabolism pathway.
If you are going down the alpha pathway towards 5a-DHT/ 5a-Androstanediol (= elevated values), the symptoms are usually your typical PCOS-like symptoms like facial hair, acne, anger and irritation and hair loss on the head. Males might experience pattern baldness, prostate enlargement (BPH = Benign prostatic hyperplasia). You might have completely normal levels of testosterone (please check your testosterone marker in this test to verity) and, yet, have a bad case of acne, are irritated or thinning scalp hair. If your 5a- DHT / 5a-Androstanediol is increased this would be an indication that you are favoring the alpha pathway that’s quite aggressive on your skin, hair and other places.
How to potentially address increased 5-alpha pathway preference:
The reasons for your body choosing the alpha pathway can certainly be genetic, but it is often due to inflammation, blood sugar / insulin dysregulation, having extra adipose tissue, etc.. If you can address these underlying issues then your body will balance out the alpha and beta pathways and it will improve the symptoms.
In addition to addressing the underlying conditions (inflammation, glucose/insulin dysregulation, etc), there are things that can be done from a lifestyle perspective to mitigate the symptoms by blocking the alpha pathway, such as:
(before starting a supplement regime, please consult your doctor first)
- Saw palmetto
- Stinging and dwarf nettle
- Pygeum extract (bark)
- Reishi mushroom
Our specialized data entry service is designed to seamlessly integrate your laboratory results into your private dashboard. Just send in your lab test results—whether it's an image or a file—and our skilled data entry team will handle the rest. We accommodate various file formats like PDFs, JPGs, and Excel.
The first report is complimentary. After that, the data entry service is priced at $15 per report, unless it's part of your subscribed plan. It's an ideal solution whether you have numerous reports to upload or if your schedule doesn't permit self-data entry.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
track personal results
track multiple client's results
own it for life
for health professionals
for personal lab results
own it for life
Level up your lab report analysis with our Pro plan, built for health practitioners like you.
Health Business Account
Unlock additional Pro plans when you sign up.