The DPA (Docosapentaenoic Acid) test in red blood cells (RBC) offers a comprehensive assessment of DPA levels, a key omega-3 fatty acid. DPA, found in fish oils and marine life, plays a critical role in cardiovascular health, brain function, and inflammation regulation. Measuring DPA levels in RBCs provides a more accurate and long-term indicator of omega-3 status than serum tests, reflecting the body's actual omega-3 fatty acid utilization over time. This is particularly vital for individuals at risk of heart disease, cognitive disorders, or inflammatory conditions.

The DPPX antibody test checks for autoantibodies against DPPX (DPP6), a neuronal cell-surface protein that helps regulate brain and nerve excitability. When present, these antibodies are linked to autoimmune DPPX encephalitis, a potentially treatable cause of symptoms like memory/behavior changes, agitation, tremor/myoclonus, sleep disturbance, seizures, and often prominent gastrointestinal symptoms (weight loss, diarrhea).

Celiac disease is a chronic immune-mediated inflammatory disorder with multi-systemic manifestations, both gastrointestinal and nongastrointestinal. In genetically susceptible individuals, ingestion of gluten can cause inflammation and damage to the small intestine mucosa. Celiac disease has an incidence of 1:100 in the United States.

Celiac disease is a chronic immune-mediated inflammatory disorder with multi-systemic manifestations, both gastrointestinal and nongastrointestinal. In genetically susceptible individuals, ingestion of gluten can cause inflammation and damage to the small intestine mucosa. Celiac disease has an incidence of 1:100 in the United States.

Dr. Barnes' Basal Temperature Test (BBTT) is a method used to assess thyroid function. It involves measuring the body's basal temperature upon waking. The test is based on the idea that low thyroid function can result in a lower body temperature. According to Dr. Broda Otto Barnes, who developed and promoted the test, a normal reading upon waking is around 97.8 °F (36.6 °C). If the basal temperature consistently deviates from this range, it might indicate an underactive thyroid.

The BBTT is performed by placing a thermometer in the armpit for 10 minutes immediately upon waking. While this test can provide indications of thyroid issues, it's not a definitive diagnostic tool and should be used alongside other assessments. If the test suggests thyroid dysfunction, consult a medical professional for further evaluation and treatment options.

The dRVVT Confirm (dilute Russell's Viper Venom Test Confirm) measures the presence of lupus anticoagulants (LA), autoantibodies linked to clotting disorders and antiphospholipid syndrome (APS). It compares screening and confirmatory test phases, with a normal ratio (0.8–1.2) indicating no significant LA interference. Elevated ratios (>1.2) suggest LA presence and possible increased clotting risk, while low ratios (<0.8) are rare and usually not clinically relevant. This test is vital for diagnosing APS and evaluating unexplained blood clots or recurrent pregnancy loss, providing key insights for managing autoimmune or clotting conditions.

Dilute Russell's viper venom time (dRVVT) is a laboratory test often used for detection of lupus anticoagulant (LA). Russell's viper venom [RVV] isolated from the snake Daboia russelii contains a potent activator of factor X which in the presence of phospholipid, prothrombin and calcium ions clots fibrinogen to fibrin. In individuals with a lupus anticoagulant the antibody binds to the phospholipid inhibiting the action of the RVV and prolonging the clotting time. 

The dRVVT Screen Ratio is a key component of lupus anticoagulant (LA) testing. It is calculated from the dilute Russell's viper venom time (dRVVT) screen test, which uses a low-phospholipid reagent to increase sensitivity to lupus anticoagulant. A normal dRVVT screen ratio is typically less than 1.20, while an elevated ratio (≥1.20) may suggest the presence of LA. However, elevated results can also arise from coagulation factor deficiencies, anticoagulant medications, or other inhibitors.

The screen ratio is determined by dividing the patient’s plasma clotting time by the clotting time of normal pooled plasma. When the ratio is elevated, additional tests, such as mixing studies and confirmatory assays, are often performed to distinguish lupus anticoagulant from other causes of prolonged clotting times.

Evaluating patients with signs and symptoms consistent with systemic lupus erythematosus (SLE).

The anti-double stranded DNA (anti-dsDNA) tests are used to help diagnose and monitor lupus, also called systemic lupus erythematosus or SLE, a chronic inflammatory autoimmune disorder in which the immune system mistakenly targets the body’s own cells and tissues.

The "Dust Mite (Dermatophagoides pteronyssinus) IgE" test measures your body's immune response to a common allergen found in household dust mites. Dust mites, tiny creatures invisible to the naked eye, thrive in warm, humid environments like bedding, carpets, and furniture. When you inhale or come into contact with dust containing these mites, your immune system may react by producing specific antibodies called IgE (Immunoglobulin E) if you’re sensitive to them.

Biomarkers:

- IAD/Methane Score

- PP Bacteria/Yeast

- Reference Variance

- Total Abundance

Therapeutic Support Options: 

Therapeutic support options are static to serve as potential treatment ideas. Clinician discretion is advised when selecting appropriate therapeutics for individual patients.

- Pre-/Probiotics

- Increase Dietary Fiber Intake

- Consider SIBO Testing

- Increase Resistant Starches

- Increase Fermented Foods

- Meal Timing

Genova’s data analysis has led to the development of unique dysbiosis patterns, related to key physiologic disruptions, such as immunosuppression and inflammation. These patterns may represent dysbiotic changes that could pose clinical significance.