Melatonin (Waking)


A healthy result should fall into the range 10 - 85 ng/mg.

Melatonin is a hormone produced in the pineal gland in response to light therefore, among many things, it regulates the sleep-wake cycle or circadian rhythm and is also a very powerful antioxidant. The pineal gland is a pea-sized gland located just above the middle of the brain. During the day the pineal is inactive. When the sun goes down and darkness occurs, the pineal is "turned on" and begins to actively produce melatonin, which is released into the blood. Usually, this occurs around 9 pm. As a result, melatonin levels in the blood rise sharply and you begin to feel less alert. Sleep becomes more inviting. Melatonin levels in the blood stay elevated for about 12 hours - all through the night - before the light of a new day when they fall back to low daytime levels by about 9 am. Daytime levels of melatonin are barely detectable.

Urinary 6-Sulfatoxymelatonin (MT6s) is the main metabolite of melatonin. MT6s itself has no physiologic activity, but testing it in the urine is a good indicator of whole body melatonin production. Low urinary MT6s is an indication for melatonin supplementation. It is normal to see elevated urinary values with supplemented doses higher than 1mg.

Studies have shown that monitoring this metabolite in the urine collected upon waking correlates to the night’s production of melatonin.

Melatonin (Waking) result calculator

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