Quinolinate is a neurotoxin derived from tryptophan. Elevated quinolinate is seen in brain and nerve tissue damage, especially in disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, motor neuron diseases, multiple sclerosis, epilepsy, amyotrophic lateral sclerosis, and major depressive disorder. We can also see elevated quinolinate due to low serotonin and need for vitamin B3 (niacin). The causes of elevated quinolinate include neuroinflammation, general inflammation, infection, phthalate exposure, and/or oral tryptophan use.
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High levels might be associated with mental illness, ALS, alzheimer's and depression. Studies have demonstrated that quinolinic acid may be involved in many psychiatric disorders, neurodegenerative processes in the brain, as well as other disorders such as mental illness, ALS, alzheimer's and depression.
Increased levels of quinolinic acid have also been detected in Lyme patients with central nervous system inflammation.
The following substances have been proven to lower levels of quinolinic acid:
- Sulforaphane [R]
- Selenium [R]
- Melatonin [R]
- Theanine [R]
- Green Tea Polyphenols [R]
- Curcumin + Piperine [R]
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