Bilophila wadsworthia

Low levels of Bilophila wadsworthia in the gut may have potential implications for metabolic health and host-microbiota interactions. Bilophila wadsworthia is a Gram-negative sulfite-reducing bacterium that has been associated with certain dietary patterns and metabolic dysfunctions.

Research has shown that dietary lipids, particularly high-fat diets, favor the growth of Bilophila wadsworthia in the gut. When combined with a high-fat diet, B. wadsworthia has been found to promote higher inflammation, intestinal barrier dysfunction, and bile acid dysmetabolism. This, in turn, leads to higher glucose dysmetabolism and hepatic steatosis, which is the accumulation of fat in the liver. The bacterium's expansion seems to play a role in exacerbating the negative effects of a high-fat diet on metabolic health.

Moreover, B. wadsworthia has been associated with negative consequences on glycemic control and hepatic function. Studies have indicated that the over-representation of B. wadsworthia may induce a negative impact on intestinal inflammation, making it relevant in the context of metabolic syndrome and its associated diseases, such as type 2 diabetes and non-alcoholic fatty liver disease.

Furthermore, there is evidence to suggest that B. wadsworthia may be involved in gut microbial responses to specific diets. For instance, it has been observed that vegetarians and vegans have lower ratios of Bilophila wadsworthia compared to omnivores, suggesting that diet composition may influence the abundance of this bacterium in the gut.

In another study, raspberry consumption was found to impact gut microbial composition, and an increase in Bilophila wadsworthia was associated with higher levels of trimethylamine N-oxide (TMAO) in the blood. TMAO is a metabolite produced by gut microbes, and its elevated levels have been linked to the gut-liver axis and potential proinflammatory effects.

Overall, low levels of Bilophila wadsworthia in the gut may indicate a potential protective role against certain metabolic dysfunctions associated with high-fat diets, while higher levels might be linked to increased inflammation, altered bile acid metabolism, and impaired glycemic control. However, it's essential to note that the research on Bilophila wadsworthia and its effects on metabolic health is still in the early stages, and more studies are needed to fully understand the complex interactions between this bacterium and the host's metabolic processes.

Bilophila Wadsworthia is a gram negative, anaerobic, sulfidogenic bacterium resistant to β-lactam antibiotics. This pathobiont is commonly found in patients with appendicitis and it has been associated to the Western diet (high in fats and animal proteins), as well as severe malnutrition. A recent study in animals showed that a high fat diet stimulates the growth of B. Wadsworthia, which causes inflammation, dysfunction in the intestinal barrier and bile acid metabolism, hepatic steatosis and dysfunctional glucose metabolism. Interestingly, the co-administration of a probiotic strain (Lactobacillus rhamnoses) reduces the generated inflammation and limits the metabolic impairment.