Klebsiella pneumoniae is a facultative anaerobe, gram-negative bacterium. Similar to K. oxytoca, it is an antibiotic resistant strain usually causing extra-intestinal nosocomial infections like liver, urinary infections and, above all, pneumonia. Klebsiella pneumoniae has been linked with development of Ankylosing spondylitis. High alcohol producing strains of K. pneumoniae have been linked with increased occurrence of fatty liver disease (non-alcoholic steatohepatitis, or NASH) Klebsiella pneumoniae has the potential to decarboxylate histidine to histamine.
References:
Navon-Venezia, S., Kondratyeva, K. & Carattoli, A. Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance. FEMS Microbiol. Rev. 41, 252–275 (2017).
Paczosa, M. K. & Mecsas, J. Klebsiella pneumoniae: Going on the Offense with a Strong Defense. Microbiol. Mol. Biol. Rev. 80, 629–661 (2016).
Zhu, W. et al. Ankylosing spondylitis: etiology, pathogenesis, and treatments. Bone Res. 7, (2019).
Yuan, J. et al. Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae. Cell Metab. 30, 675- 688.e7 (2019).
Klebsiella pneumoniae
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