Bacteroides ovatus had been shown to elicit the largest IgG and IgA responses in Crohn’s patients of the commensal bacteria.
Why Bacteroides ovatus induces such as response is not totally known, but it does produce esterase and lipase which can be potentially hazardous to the intestinal tissue, especially if initial damage has been created by a bacterial toxin such as Enterotoxigenic Bacteroides fragilis (ETBF). Bacteriodes ovatus plays an important role of degrading inulin, which the metabolites of in turn feeds Bacteroides vulgatus and supports the colony, so they have a syntrophic relationship.
References:
Saitoh, S. et al. Bacteroides ovatus as the Predominant Commensal Intestinal Microbe Causing a Systemic Antibody Response in Inflammatory Bowel Disease. Clin. Diagn. Lab. Immunol. 9, 54–59 (2002).
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