ASCA/ANCA IgA+IgM

Optimal Result: 0 - 2.4 ELISA Index.

Saccharomyces cerevisae, baker’s yeast, contains Chl1p, a putative helicase with human homologs (antiSaccharamyces cerevisae antibody – ASCA). It is required for DNA repair, recombination, transcriptional silencing and aging. Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies produced against antigens in the cytoplasm of neutrophil granulocytes and monocytes.

Known Cross-Reactions: Mannan, enteric bacterial antigens

Antibodies Appear: Crohn’s disease, Sjögren’s syndrome

References:

Fresko, et al. Anti-Saccharomyces cerevisae antibodies (ASCA) in Behçet’s syndrome. Clin Exp Rheumatol, 2005; 23(Suppl.38):S67-S70.

Font, et al. Antineutrophil cytoplasmic antibodies in primary Sjögren's syndrome: prevalence and clinical significance. Rheumatol, 1998; 37(12):1287-1291.

Gómez-Puerta, et al. Antineutrophil cytoplasmic antibody-associated vasculitides and respiratory disease. Chest, 2009; 136:1011-1111.

Lindberg, et al. Antibody (IgG, IgA, and IgM) to baker's yeast (Saccharomyces cerevisiae), yeast mannan, gliadin, ovalbumin and betalactoglobulin in monozygotic twins with inflammatory bowel disease. Gut, 1992; 33(7):909–913.

Nisihara, et al. Diagnostic role and clinical association of ASCA and ANCA in Brazilian patients with inflammatory bowel disease. Dig Dis Sci, 2010; 55(8):2309-2315.

Seibold, et al. pANCA represents a cross-reactivity to enteric bacterial antigens. Clin Immunol, 1998; 18(2):153-160.

Thomsen, et al. Anti-saccharomyces cerevisiae antibodies (ASCA) are present in the saliva of Crohn's disease patients and are useful as an alternative to serum antibodies for diagnosis of Crohn's disease. Gastroenterol, 2000; 95:2503.013; 4:20-32.

What does it mean if your ASCA/ANCA IgA+IgM result is too high?

Elevated salivary antibodies to ASCA have been detected in patients with diagnosed Crohn’s disease when compared to non-irritable bowel disease and non-disease control groups.

Elevated salivary antibodies to ANCA have been detected in patients with diagnosed Sjögren’s syndrome coupled with vascular manifestations, including cutaneous vasculitis, Raynaud’s phenomenon and peripheral neuropathy.

Serum ASCA and ANCA antibodies are well-established markers in inflammatory bowel disease (IBD), and both may be associated with disease phenotype.

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