Gamma-Gliadin-15-mer IgA+IgM
Gliadin is a glycoprotein. It is an alcohol-soluble protein present in wheat and occurring in various forms (a-, g-, and w-gliadins). g-Gliadins-15-mer are considered to be the most ancient of the gluten family. This group of gliadins works with gluten proteins to determine the functional properties of wheat flour.
Known Cross-Reactions: Cerebellar
References:
Altenbach, et al. Analysis of expressed sequence tags from a single wheat cultivar facilitates interpretation of tandem mass spectrometry date and discrimination of gamma gliadin proteins that may play different functional roles in flour. BMC Plant Biol, 2010; 10:7-21.
Camarca, et al. Intestinal T cell responses to gluten peptides are largely heterogeneous: implications for a peptide-based therapy in celiac disease. Immunol, 2009; 182:4158-4166.
Qi, et al. The g-gliadin multigene family in common wheat (Triticum aestrivum) and its closely related species. BMC Genomics, 2009; 10:168-182.
Vojdani, et al. Immune response to dietary proteins, gliadin and cerebellar peptide in children with autism. Nutr Neurosci, 2004; 7(3):151-161.
What does it mean if your Gamma-Gliadin-15-mer IgA+IgM result is too high?
Associated With: Loss of oral tolerance
The presence of salivary antibodies to g-Gliadin is an indication of loss of mucosal tolerance and the onset of food immune reactivity. Gliadin contains the toxic peptides associated with Celiac Disease (CD). Multiple gliadins plus glutenin make up the gluten family of proteins that may trigger immune reactivity in patients. Assessing immune reactivity to a variety of wheat proteins increases the sensitivity for wheat/gluten reactivity. Detection of antibodies to gliadin may indicate abnormal mucosal immune response and intestinal barrier dysfunction. Coupled with Transglutaminase antibodies testing, Gliadin antibody assay results can assist with diagnosing potential CD and Gluten Reactivity (GR). If both are positive, the patient most likely developing CD. If Gliadin is positive and Transglutaminase negative the patient could be suffering from GR without enteropathy. If Transglutaminase is positive and Gliadin is negative the patient could be suffering from autoimmunity other than CD and GR. g-gliadins have unusually high levels of glutamine and proline. In Camarca’s T-cell study, a great majority of subjects responded to g-gliadin, leading the scientists to suggest that g-gliadin plays a significant role in the pathogenesis of Celiac disease.
All Your Lab Results.
One Simple Dashboard.
Import, Track, and Share Your Lab Results Easily
Import, Track, and Share Your Lab Results
Import lab results from multiple providers, track changes over time, customize your reference ranges, and get clear explanations for each result. Everything is stored securely, exportable in one organized file, and shareable with your doctor—or anyone you choose.
Cancel or upgrade anytime
Laboratories
Bring All Your Lab Results Together — In One Place
We accept reports from any lab, so you can easily collect and organize all your health information in one secure spot.
Pricing Table
Gather Your Lab History — and Finally Make Sense of It
Finally, Your Lab Results Organized and Clear
Personal plans
$79/ year
Advanced Plan
Access your lab reports, explanations, and tracking tools.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 5 reports entered for you
- Cancel or upgrade anytime
$250/ once
Unlimited Account
Pay once, access everything—no monthly fees, no limits.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 10 reports entered for you
- No subscriptions. No extra fees.
$45/ month
Pro Monthly
Designed for professionals managing their clients' lab reports
- Import lab results from any provider
- Track lab results for multiple clients
- Customize reference ranges per client
- Export lab histories and reports
- Begin with first report entered by us
- Cancel or upgrade anytime
About membership
What's included in a Healthmatters membership
Import Lab Results from Any Source
See Your Health Timeline
Understand What Your Results Mean
Visualize Your Results
Data Entry Service for Your Reports
Securely Share With Anyone You Trust
Let Your Lab Results Tell the Full Story
Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.
Bring all your results together to compare, track progress, export your history, and share securely.
What Healthmatters Members Are Saying
Frequently asked questions
Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
- Individuals who want to track and understand their health over time.
- Health professionals, such as doctors, nutritionists, and wellness coaches, need to manage and interpret lab data for their clients.
With a Healthmatters account, you can:
- Upload lab reports from any lab
- View your data in interactive graphs, tables, and timelines
- Track trends and monitor changes over time
- Customize your reference ranges
- Export and share your full lab history
- Access your results anytime, from any device
Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 10000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
- The GI Effects® Comprehensive Stool Profile,
- GI-MAP,
- The NutrEval FMV®,
- The ION Profile,
- Amino Acids Profile,
- Dried Urine Test for Comprehensive Hormones (DUTCH),
- Organic Acids Test,
- Organix Comprehensive Profile,
- Toxic Metals,
- Complete Blood Count (CBC),
- Metabolic panel,
- Thyroid panel,
- Lipid Panel,
- Urinalysis,
- And many, many more.
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
We implement proven measures to keep your data safe.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.