Rotavirus IgA+IgM
Human rotaviruses belong to the family of Reoviridae. Rotavirus is a double-stranded RNA virus that is commonly associated with gastroenteritis in children.
Known Cross-Reactions: Pollen allergen of Parietaria
References:
Aiyar, et al. Rotavirus-specific antibody response in saliva of infants with rotavirus diarrhea. J Infect Dis, 1990; 162:1383-1384.
Di Somma, et al. Cross-reactivity between the major Parietaria allergen and rotavirus VP4 protein. Allergy, 2003; 58(6):503-510.
Hjelt, et al. Antibody response in serum and intestine in children up to six months after a naturally acquired rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr, 1986; 5:74-80.
Mestecky and McGhee. Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv Immunol, l987; 40:153-245.
Molyneaux. Human immunity to rotavirus. Med Microbiol, 1995; 43:397-404.
Ward, et al. Salivary antibody titers in adults challenged with a human rotavirus. Med Virol, 1992; 36:222-225.
What does it mean if your Rotavirus IgA+IgM result is too high?
The detection of salivary antibodies to Rotavirus in an infant may indicate either mucosal immune protection in the absence of diarrhea, or if accompanied by diarrhea, current/recent onset Rotavirus infection.
In adults, elevated salivary antibody production to Rotavirus has been shown to indicate active or recent infection.
In one study of injected adults, antibodies rose four-fold after 13 days and then decreased significantly by 27 days after injection of the virus. Hjelt and colleagues found that secretory immunoglobulins could persist even after one month of naturally-occurring infection in children and in some subjects, elevated antibodies were found several months later.
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