Mixed Heavy Metals IgA+IgM
Optimal Result:
0 - 1.9 ELISA Index.
Mixed Heavy Metals (Nickel, Cobalt, Cadmium, Lead, Arsenic) are ubiquitous compounds found in soil, drinking water and food supply, and are not fully avoidable. However, certain exposures can be limited or controlled. These include the exposure of Heavy Metals from manufactured goods, cigarette smoke, paints, gasoline, and some food containers and cookware. Arsenic is absorbed by all plants, but is more concentrated in leafy vegetables, rice, apple and grape juice, and seafood.
References:
Büdinger and Hertl. Immunologic mechanisms in hypersensitivity reactions to metal ions: an overview. Allergy, 2000; 55:108-115.
Carey, et al. Immune modulation by cadmium and lead in the acute reporter antigen-popliteal lymph node assay. Toxicologic Sci, 2006; 91(1):113-122.
Järup. Hazards of heavy metal contamination. Br Med Bulletin, 2003; 68:167-182.
Seldén, et al. Exposure to cobalt chromium dust and lung disorders in dental technicians. Thorax, 1995; 50:769-772.
Thierse, et al. Metal-protein complex-mediated transport and delivery of Ni2 to TCR/MHC ontact sites in nickel-specific human T cell activation. Immunology, 2004; 172:1926-1934.
WHO. Lead. Environmental Health Criteria, vol. 165. Geneva: World Health Organization, 1995.
Xu, et al. Effect of co-exposure to nickel and particulate matter on insulin resistance and mitochondrial dysfunction in a mouse model. Particle Fibre Toxicol, 2012; 9:40.
Lab Results Explained and Tracked
What does it mean if your Mixed Heavy Metals IgA+IgM result is too high?
The presence of salivary antibodies to Mixed Heavy Metals (Nickel, Cobalt, Cadmium, Lead, Arsenic) bound to human protein is an indication heavy metals binding to human tissue proteins and loss of tolerance against heavy metal-bound tissue antigen. Once infiltrating the human body, the heavy metal or its metabolites can bind to human tissue proteins and form neo-antigens. These new antigens are comprised of the haptenic chemical plus the tissue antigen. The formation of neo-antigens initiates an immune response which may result in antibody production against the chemical and the human tissue. Continued exposure to the chemical and the subsequent production of antibodies against various tissue antigens, may result in autoimmune reactivity. Persons with salivary antibodies to Mixed Heavy Metals bound to human proteins should remove or limit exposure to the substances where reasonably controllable.
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