Neurotransmitters

Norepinephrine

Optimal Result: 19 - 76 ug/g creat.

Norepinephrine, also known as noradrenaline, is important for mental focus and emotional stability.

Norepinephrine functions as a neurotransmitter and hormone that regulates the “fight or flight” response and elevates blood pressure and heart rate, stimulates wakefulness, and reduces digestive activity.

Norepinephrine is an excitatory neurotransmitter.

Neurotransmitters are divided into two basic categories:

– Excitatory neurotransmitters stimulate the brain and body.

– Inhibitory neurotransmitters calm the brain and body.

Just as levels of individual neurotransmitters are important in maintaining optimum health, so is the proper balance between your excitatory and inhibitory systems.

Norepinephrine is synthesized from dopamine by means of the enzyme dopamine beta-hydroxylase, with oxygen, copper, and vitamin C as co-factors. Dopamine is synthesized in the cytoplasm, but norepinephrine is synthesized in the neurotransmitter storage vesicles. Cells that use norepinephrine for formation of epinephrine use SAMe as a methyl group donor.

Norepinephrine acts as an excitatory neurotransmitter and modulates neuron voltage potentials to favor glutamate activity and neurotransmitter firing.

What does it mean if your Norepinephrine result is too low?

Low levels of Norepinephrine contribute to a decrease in mood, energy, focus, motivation and memory.

Norepinephrine functions both as a neurotransmitter and a hormone, participating in the body’s fight or flight response. Norepinephrine increases alertness, focuses attention, fine-tunes vigilance, increases blood pressure, heart rate, and blood glucose, reduces digestive activity, pain and sleep, prevents bladder emptying, and regulates body temperature. The adrenal gland produces approximately 20% of norepinephrine with 80% produced by the sympathetic nerve fibers. Research shows that urinary norepinephrine is reduced in patients with Alzheimer’s disease.

Clinically, low norepinephrine is implicated in anorexia, attention impairment, depression, fatigue, hypotension, lack of motivation, lethargy, low mood, memory issues, slow pulse rate, and weight issues.

In addition low levels of norepinephrine can be related to:

- Lack of energy

- Lack of focus

- Lack of motivation

- Attention impairment

- Depression

- Fatigue

- Hypotension

- Low mood

Can also be seen in:

- Alzheimer’s disease

- Anorexia

Possible treatment:

If norepinephrine is low, precursor supplementation with tyrosine or phenylalanine, or cofactor support with ascorbic acid, iron, tetrahydrofolic acid, and vitamin B6 may be beneficial. Consult your doctor before starting any supplementation.

What does it mean if your Norepinephrine result is too high?

Elevated norepinephrine activity seems to be a contributor to anxiousness. Also, brain norepinephrine turnover is increased in conditions of stress. Interestingly, benzodiazepines, the primary anxiolytic drugs, decrease firing of norepinephrine neurons. This may also help explain the reasoning for benzodiazepine use to induce sleep.

High levels are associated with aggression, anxiety, emotional lability, hyperactivity, mania, stress and suppression of the immune system.

In addition high levels of norepinephrine can be related to:

- Stress

- Hyperactivity

- High blood pressure

- ADD

- Anxiety and depression

- Bipolar disorder

- Hyperglycemia

- Hyperinsulemia

- Obesity

- Obstructive sleep apnea

- PTSD

- Stress

Our database has science-based research on 1500+ biomarkers.

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Essential Plan


  • Monthly subscription
  • Instant interpretation
  • Use the free self-upload form
  • Additional charge for upload service
  • 1500+ biomarkers explained
  • Recommendations
  • Cancel anytime

Advanced Plan


  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 1500+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium plan


  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 1500+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals