Gamma-aminobutyric acid (GABA)

Neurotransmitters

A healthy result should fall into the range 2.4 - 12.7 uMol/gCr.

GABA stands for Gamma-aminobutyric acid (γ-Aminobutyric Acid) and is a nonessential protein amino acid. GABA is an inhibitory neurotransmitter in the central nervous system.

In the brain, GABA is produced from glutamate in a single decarboxylation reaction. Isoforms of glutamic acid decarbocylase, the enzyme used for conversion, are expressed in tissues other than the brain, where they play a role in diseases of autoimmune character, including neurological disorders and insulin-dependent diabetes.

Neurotransmitters are the chemical messengers used by neurons to communicate with one another and with other types of cells. Every neurotransmitter behaves differently; inhibitory neurotransmitters tend to calm, while excitatory neurotransmitters tend stimulate the brain.

GABA’s primary function:

GABA’s primary function as the brain’s major inhibitory neurotransmitter is to prevent overstimulation. It does this by counteracting glutamate—the brain’s major excitatory neurotransmitter. When GABA binds to a receptor, it prevents stimulation by glutamate. When GABA levels are inadequate, overstimulation due to high levels of glutamate can occur and lead to symptoms of low GABA.

References:

Gamma-aminobutyric acid (GABA) result calculator

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