Neurotransmitters

Gamma-aminobutyric acid (GABA)

Optimal Result: 2.4 - 12.7 uMol/gCr.

GABA stands for Gamma-aminobutyric acid (γ-Aminobutyric Acid) and is a nonessential protein amino acid. GABA is an inhibitory neurotransmitter in the central nervous system.

In the brain, GABA is produced from glutamate in a single decarboxylation reaction. Isoforms of glutamic acid decarbocylase, the enzyme used for conversion, are expressed in tissues other than the brain, where they play a role in diseases of autoimmune character, including neurological disorders and insulin-dependent diabetes.

Neurotransmitters are the chemical messengers used by neurons to communicate with one another and with other types of cells. Every neurotransmitter behaves differently; inhibitory neurotransmitters tend to calm, while excitatory neurotransmitters tend stimulate the brain.

GABA’s primary function:

GABA’s primary function as the brain’s major inhibitory neurotransmitter is to prevent overstimulation. It does this by counteracting glutamate—the brain’s major excitatory neurotransmitter. When GABA binds to a receptor, it prevents stimulation by glutamate. When GABA levels are inadequate, overstimulation due to high levels of glutamate can occur and lead to symptoms of low GABA.

References:

https://www.ncbi.nlm.nih.gov/pubmed/19058788

https://www.ncbi.nlm.nih.gov/pubmed/21969419

https://www.ncbi.nlm.nih.gov/pubmed/23861191

https://www.ncbi.nlm.nih.gov/pubmed/23391588

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327859/

https://www.ncbi.nlm.nih.gov/pubmed/23853635

https://www.ncbi.nlm.nih.gov/pubmed/22207903

https://www.ncbi.nlm.nih.gov/pubmed/16952998

https://www.ncbi.nlm.nih.gov/pubmed/23522493

https://www.ncbi.nlm.nih.gov/pubmed/11837891

What does it mean if your Gamma-aminobutyric acid (GABA) result is too low?

Low levels in plasma are characterized of one subset of patients with depression. The neurodegenerative condition, Huntington’s disease, also manifests as lowered levels of GABA as neuron loss proceeds. Vitamin B6 deficiency impairs GABA formation, offering one option to help assist patients with inadequate GABA production.

Low GABA levels have been found in:

- panic anxiety

- depression

- alcoholism

- bipolar disorders

What does it mean if your Gamma-aminobutyric acid (GABA) result is too high?

High levels may reflect decreased ability to convert to succinate for use in the Krebs (citric acid) cycle for energy generation. Cofactors here are α-KG and vitamin B6.

Understand blood, stool, and urine medical results from your labs.

10 000+ happy clients
100% satisfaction
★★★★★ customer support

Get 10% off of your first yearly or monthly plan.

Use promocode

Essential Plan


  • Monthly subscription
  • Instant interpretation
  • Use the free self-upload form
  • Additional charge for upload service
  • 2000+ biomarkers explained
  • Recommendations
  • Cancel anytime

Advanced Plan


  • Yearly subscription
  • Instant interpretation
  • We upload five reports for you
  • Use the free self-upload form
  • 2000+ biomarkers explained
  • Nutrition Recommendations
  • Online support
  • Cancel anytime

Own It For Life premium plan


  • No subscription
  • Unlimited access
  • Unlimited storage
  • Instant interpretations
  • We upload ten reports for you
  • Use the free self-upload form
  • 2000+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Healthmatters.io software for professional use.

Welcome to Healthmatters Pro.

Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place.

Learn More


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

General Data Protection Regulation (GDPR). HIPAA compliance for healthcare professionals
×

Understand Your Lab Result Now

  • Instant interpretation
  • 2000+ biomarkers explained
  • Science-based recommendations
  • Online support
  • Secure and private portal

Get 10% off with promocode:

;