3,4-Dihydroxyphenylacetic acid (DOPAC)

Neurotransmitters

A healthy result should fall into the range 360 - 1800 ug/g creat.

Dopac (aka 3,4-Dihydroxyphenylacetic acid) is a metabolite of the neurotransmitter dopamine. Dopamine serves as the reward and pleasure center in the brain. DOPAC and HVA (Homovanillic Acid) are dopamine metabolites.

DOPAC levels, when viewed in conjunction with dopamine levels, may provide insight into how the body processes neurotransmitters.

Some of the enzymes that degrade dopamine are only found in specific regions of the body. As such some dopamine metabolites are only produced in specific tissues. Understanding how and where these enzymes function can provide valuable insight into how dopamine is functioning in specific regions of the body. In order to understand these functions, one must first realize Monoamine oxidase (MAO) is an enzyme present within the cytoplasm of neurons that breaks down dopamine to DOPAL. DOPAL, in turn, is very rapidly converted to DOPAC by a second cytoplasmic enzyme aldehyde dehydrogenase (AD). Because both of these enzymes are primarily found inside neurons, DOPAC levels are dependent on the amount of cytoplasmic dopamine. Combined measurements of DOPAC and dopamine have been used to assess the activity of dopaminergic neurons. This combination provides additional information than either parameter alone because a large portion of DOPAC is formed from dopamine without ever being released to the synaptic cleft. This suggests that DOPAC may be more closely related to the presynaptic dopamine levels while dopamine and similarly HVA levels, another important metabolite of dopamine that is formed outside of the neuron via the actions of catechols-O-methyltransferase (COMT), is related to the rate of neuron signaling. Said another way, extracellular DOPAC is related to the amount of dopamine made and stored in the presynaptic neuron while extracellular dopamine levels are related to the rate of dopamine released via the depolarization of dopamine neurons.

References:

-https://www.researchgate.net/figure/The-metabolism-of-dopamine-into-DOPAC-3-4-dihydroxyphenylacetic-acid-and-3-MT_fig8_237098396

-http://www.hmdb.ca/metabolites/HMDB0001336

-https://www.acam.org/blogpost/1092863/229831/Advances-in-Neurotransmitter-Testing-The-Intermediaries-of-the-Neuro-biogenic-Amines

-https://www.ncbi.nlm.nih.gov/pubmed/19945170

-https://www.ncbi.nlm.nih.gov/pubmed/23892640

-https://www.ncbi.nlm.nih.gov/pubmed/1583475

-https://www.ncbi.nlm.nih.gov/pubmed/21806773

-https://www.ncbi.nlm.nih.gov/pubmed/1718014

-https://www.ncbi.nlm.nih.gov/pubmed/22200523

-https://www.ncbi.nlm.nih.gov/pubmed/15082158

-https://www.ncbi.nlm.nih.gov/pubmed/23850225

-https://www.ncbi.nlm.nih.gov/pubmed/21806773

3,4-Dihydroxyphenylacetic acid (DOPAC) result calculator

insert the value from you 3,4-Dihydroxyphenylacetic acid (DOPAC) test result.

Is your 3,4-Dihydroxyphenylacetic acid (DOPAC) too high or too low?
Upload your lab report and instantly interpret your result.

DIY Health One

One Lab Report Interpretation

  • One lab report interpretation
  • Use self upload form
  • 800+ biomarkers explained
  • Recommendations
  • Pay per additional interpretations
  • Report uploading support*

15 $

Analyze and Interprete Now

*Additional costs may apply

DIY Health Track

Unlimited Lab Report Interpretations

  • Unlimited lab report interpretations
  • Use self upload form
  • 800+ biomarkers explained
  • Recommendations
  • Online support
  • We do the uploading for you*

59 $/year

Analyze and Interprete Now

*4 report uploads by our team are included per year

Sign Up, Upload Tests, Get Insights and Improve with HealthMatters.io.

Sign up now

Your Privacy And Security

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put security measures in place to help protect against the loss, misuse or alteration of information under our control. We use procedural, physical and electronic security methods designed to prevent people who aren't authorized from getting access to this information. Our internal code of conduct adds additional privacy protection. See our Privacy Policy for more information.