Optimal Result:
600 - 2000 ng/mg.
Pregnanediol is a metabolite of the molecule of progesterone, which is important for fertility and for menstruation. Pregnanediol levels increase after ovulation and when the placenta releases the hormone.
When pregnanediol levels fall during a menstrual cycle, it means that progesterone levels are less than ideal. It results in symptoms during the luteal phase.
During the adaptation of the body to menopause, progesterone levels fall and estrogen dominance begins. That’s when progesterone supplements may be offered to manage the symptoms. Some of the symptoms include hot flashes, vaginal dryness, mood instability, low sex drive, sleep problems, brain fog, hair loss, loss of muscle mass and strength, weight gain and anxiety.
Various normal ranges*:
- Luteal (premenopausal) Range: 600 - 2000 ng/mg
- Postmenopausal Range: 60-200 ng/mg
- Follicular Range: 100-300 ng/mg
- Ovulatory Range: 100-300 ng/mg
- Oral Progesterone (100mg) - Range: 2000-9000 ng/mg
*the Luteal Range is the premenopausal range. When patients are taking oral progesterone this range for progesterone metabolites is not luteal and reflects the higher levels expected when patients take oral progesterone. This test is intended to be taken in the luteal phase of the menstrual cycle (days 19-22 of a 28 day cycle) for premenopausal women.
Sources:
http://www.labtesthelp.com/test/Pregnanediol
http://meridianvalleylab.com/wp-content/uploads/2016/06/Urine-Hormone-Interp-Guide.pdf
Generally high progesterone levels indicate you are high for the luteal phase.
High progesterone metabolites can occur with progesterone or pregnenolone supplementation.
It can also occur with stress as the adrenals release more progesterone during stress, although ovarian production will exceed adrenal production with ovulation.
High progesterone is also seen in PCOS when ovulation occurs because of excessive luteinizing hormone secretion. Some women may naturally make high levels of progesterone and, if symptom free, it is usually not concerning. Symptoms of high progesterone may include bloating, fatigue and food cravings, especially high calorie foods.
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Important note: the Luteal Range is the premenopausal range. When you are taking oral progesterone this range for progesterone metabolites is not luteal and reflects the higher levels expected when people take oral progesterone.
The Oral Progesterone (100mg) - Range is 2000-9000 ng/mg
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b-Pregnanediol, also known as pregnanediol, is a metabolite of progesterone, a hormone that plays a crucial role in the menstrual cycle and in maintaining the early stages of pregnancy. The levels of b-pregnanediol are often measured through urine tests to reflect the amount of progesterone produced by the body.
The luteal phase is the latter phase of the menstrual cycle or the period between ovulation and the start of menstruation. During the luteal phase, the corpus luteum (which is formed in the ovaries from the follicle that has released an egg) produces progesterone. The role of progesterone is to prepare the uterine lining for a potential pregnancy.
If your b-pregnanediol levels are low during the luteal phase (luteal range), it suggests that your body is not producing enough progesterone during a time when it should be at its peak.
Low levels of b-Pregnanediol during the luteal phase can be attributed to various factors, including:
→ Luteal Phase Defect: An inadequately functioning corpus luteum can lead to insufficient progesterone production.
→ Hypothalamic Amenorrhea: Stress, low body weight, and excessive exercise can lead to a condition where the hypothalamus stops triggering the hormonal cycle that causes ovulation and menstruation.
→ Poor Ovarian Reserve: Diminished ovarian reserve can lead to decreased hormone production, including progesterone.
→ Ovulatory Disorders: Conditions such as polycystic ovary syndrome (PCOS) can disrupt the normal ovulation process, leading to lower progesterone levels.
→ Hyperprolactinemia: Elevated levels of prolactin can interfere with the secretion of hormones necessary for ovulation, affecting progesterone production.
→ Thyroid Dysfunction: Both hyperthyroidism and hypothyroidism can affect menstrual cycles and hormonal balance, including progesterone levels.
→ Stress and Lifestyle Factors: Chronic stress can disrupt the hypothalamic-pituitary-gonadal axis, affecting hormone production. Extreme weight loss or gain and poor nutrition can also play a role.
→ Adrenal Disorders: Since the adrenal glands produce precursor hormones that lead to progesterone production, disorders of the adrenal glands can affect b-pregnanediol levels.
→ Medications: Certain medications, including those that affect hormone production like steroids or those used in chemotherapy, can influence progesterone levels.
→ Premature Ovarian Failure: Also known as primary ovarian insufficiency, this condition involves the loss of normal ovarian function before age 40, affecting hormone levels.
→ Congenital Adrenal Hyperplasia: A group of inherited disorders affecting the adrenal glands can lead to an imbalance in steroid hormone production, including progesterone.
→ Environmental Factors: Exposure to certain environmental toxins or endocrine-disrupting chemicals may potentially affect hormone levels.
Low levels of b-pregnanediol, which reflect low levels of progesterone, can lead to a variety of reproductive and health issues, including:
→ Infertility: Since progesterone is essential for creating a supportive environment for a fertilized egg, low levels can make it difficult to conceive.
→ Menstrual Irregularities: Progesterone helps regulate the menstrual cycle; low levels can lead to irregular or missed periods.
→ Miscarriage: Adequate progesterone levels are necessary to maintain the lining of the uterus during the early stages of pregnancy. Low levels can increase the risk of miscarriage.
→ Premenstrual Syndrome (PMS): Imbalances in progesterone can contribute to the symptoms of PMS.
→ Hormonal Imbalance Symptoms: Low progesterone can cause symptoms such as mood swings, anxiety, and sleep disturbances.
→ Endometrial Hyperplasia: Progesterone normally counteracts the effects of estrogen on the uterine lining. Without enough progesterone, the lining may thicken excessively, potentially leading to complications like abnormal uterine bleeding or even an increased risk of endometrial cancer.
→ Bone Density Loss: Progesterone plays a role in bone metabolism; low levels over time can contribute to reduced bone density and an increased risk of osteoporosis.
It's important to note that not all low levels of b-pregnanediol will lead to these conditions. The clinical significance depends on the individual's overall health, hormonal balance, and whether they are trying to conceive. A healthcare provider can help to assess the implications of low b-pregnanediol levels in the context of the individual's health and recommend appropriate interventions.
The treatment for low levels of b-pregnanediol generally involves addressing the underlying cause of low progesterone. Here are several approaches that might be considered:
→ Hormone Therapy: Supplementing with progesterone or its analogs can be an effective way to raise progesterone levels. This can be done through various forms such as creams, vaginal suppositories, pills, or injections, depending on the individual's needs and the doctor's recommendations.
→ Clomiphene Citrate: For women with ovulation issues, clomiphene citrate may be prescribed to stimulate ovulation, which in turn can increase progesterone production during the luteal phase.
→ Fertility Treatments: In cases of infertility, assisted reproductive technologies (ART) such as in vitro fertilization (IVF) may be used, where progesterone supplements are a standard part of the protocol.
→ Lifestyle Modifications: Improvements in diet, exercise, stress reduction, and weight management can all help to improve hormonal balance.
→ Manage Underlying Medical Conditions: Conditions like thyroid disorders, adrenal dysfunction, or PCOS may require specific medical treatments to regulate hormone production.
→ Vitamins and Supplements: Certain nutrients, such as vitamin B6, vitamin C, zinc, and magnesium, have been suggested to support progesterone levels, though their effectiveness can vary and should be discussed with a healthcare provider.
→ Herbs: Some herbal remedies are traditionally believed to support hormone balance (like chasteberry or Vitex agnus-castus), but their efficacy and safety are less well-documented, and they should only be used under the supervision of a healthcare professional.
→ Regulate Menstrual Cycles: For women not trying to conceive, oral contraceptives can be used to regulate menstrual cycles and provide a balance of hormones.
→ Reduce Stress: Since stress can impact hormone levels, techniques like mindfulness, yoga, and cognitive-behavioral therapy (CBT) may be recommended to help manage stress.
→ Monitoring and Adjusting Dosage: Regular monitoring of hormone levels through blood, saliva, or urine testing may be necessary to adjust treatment strategies to achieve optimal levels.
It's essential for any treatment plan to be developed in consultation with a healthcare provider, who can tailor the approach based on the individual's specific situation, health status, and goals (such as fertility planning). They can also monitor for side effects or interactions with other medications and adjust treatment as necessary.
Laboratories
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Import Lab Results from Any Source
Easily upload lab results from any provider, whether it's a hospital, independent lab, or home testing service. We support PDFs, scanned documents, and JPEGs from patient portals. No need to log in to multiple platforms — everything is centralized in one secure space.
Easily upload lab results from any provider — we support PDFs, scans, and images. Keep all your reports organized in one secure place.
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Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey. Whether you're tracking a condition, managing treatments, or staying proactive, the timeline helps you and your doctor understand how things progress over time.
Every lab result is automatically organized on a chronological timeline, giving you a complete picture of your health journey.
Understand What Your Results Mean
Whether it's a blood test, GI panel, urinalysis, or something else, lab reports measure numerous biomarkers that reveal what's happening inside your body. Our extensive database covers over 10,000 biomarkers, providing clear, simple explanations of what each result means and how you can take action—no matter your membership level. Say goodbye to confusion and get the insights you need to better understand your health.
Our database covers over 10,000 biomarkers with clear, simple explanations—so you can finally understand your results and what to do next.
Enter Your Lab Reports Yourself — Always Free
Enter Your Lab Reports — Always Free
If you'd like to handle inputting your health data into your account, you can do so with our easy-to-use data entry forms. Our user-friendly form is designed to guide you through the quick and easy submission process, making it simple to keep track of your health metrics. This is available to both Complete plan and Unlimited plan members.
Our user-friendly form guides you through a quick, simple submission process, making it easy to enter your health metrics.
Add your results anytime with our easy entry form. It's quick, guided, and helps you stay organized — free for all members.
Visualize Your Results
View your lab data through easy-to-read graphs and tables. Quickly spot patterns, track changes, and compare results across different dates — all without digging through multiple reports. You can also select and compare graphs of specific biomarkers side-by-side to better understand how they relate and change over time.
See your lab reports in clear graphs and tables. Spot patterns, track changes, and compare results over time — all in one place.
Export Your Complete Lab History in a Single File
Export Your Complete Lab History
After collecting lab results from different providers, you can download your entire history combined into a single file. Choose from PDF, Excel, or CSV formats to easily review, share, or get a second opinion—no more juggling multiple reports.
After collecting lab results from different providers, you can download your entire history combined into a single file.
Comprehensive Data Entry Service for Your Reports
Data Entry Service for Your Reports
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest. Complete plan members receive one report entered for free, then $15 per report after that. Unlimited plan members receive ten report entries for free, then $15 per report after that.
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest.
Securely Share With Anyone You Trust
Whether you're working with a doctor, nutritionist, caregiver, or wellness coach, you can securely share your complete lab history by sending an invite link to anyone you trust. You have full control over who sees your information and for how long, ensuring your privacy and peace of mind at every step.
Share your full lab history with your doctor, nutritionist, or coach using a secure invite link.
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I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
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As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
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Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
The Complete Plan ($15/month) is perfect for individuals who want ongoing access to their health data. It includes unlimited lab imports, visual tracking, custom ranges, result explanations, full account exports, and secure sharing — all with a simple monthly subscription. You can cancel anytime and restart your plan whenever you're ready — your data will still be there waiting for you. You can also upgrade to the Unlimited Plan at any time, with the cost prorated based on what you've already paid.
The Unlimited Plan ($250 one-time) is also designed for individuals but offers lifetime access with no ongoing subscription. You'll get all the same features as the Complete Plan, plus a larger initial data entry allowance (10 reports), making it a great choice if you prefer a one-time payment and long-term use without monthly fees.
In short:
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
Prefer to do it yourself? You can always use our free self-entry tool to add results manually — it just takes a bit more time and attention.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewExplore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Yes, you can download your information anytime. We offer two easy ways to export your lab data:
This makes it simple to save, back up, or share your health data whenever you need.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
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