A healthy result should fall into the range 600 - 2000 ng/mg.

Pregnanediol is a metabolite of the molecule of progesterone, which is important for fertility and for menstruation. Pregnanediol levels increase after ovulation and when the placenta releases the hormone. 

When pregnanediol levels fall during a menstrual cycle, it means that progesterone levels are less than ideal. It results in symptoms during the luteal phase. 

During the adaptation of the body to menopause, progesterone levels fall and estrogen dominance begins. That’s when progesterone supplements may be offered to manage the symptoms. Some of the symptoms include hot flashes, vaginal dryness, mood instability, low sex drive, sleep problems, brain fog, hair loss, loss of muscle mass and strength, weight gain and anxiety.

Normal Ranges for Pregnanediol in mg/day:

Men: 0-1.9 mg/day

Women: Follicular phase:  <2.6 mg/day

Luteal phase: 2.6-10.6 mg/day

Children 10-15 years old: 0.1-1.2 mg/day 

<9 years old: <0.5 mg/day

<2 years old: <0.1 mg/day


First trimester: 10-35 mg/day

Second trimester: 35-70 mg/day

Third trimester: 70-100 mg/day



  1. http://www.labtesthelp.com/test/Pregnanediol
  2. http://meridianvalleylab.com/wp-content/uploads/2016/06/Urine-Hormone-Interp-Guide.pdf
  3. https://www.gdx.net/product/complete-hormones-test-urine 

b-Pregnanediol result calculator

insert the value from you b-Pregnanediol test result.

What does it mean if your b-Pregnanediol result is too low?

You can have low levels of pregnanediol as well as high levels. 

Low levels of pregnanediol are associated with any of the following:  

- Breast or ovarian cancer

- Pre-eclampsia (high blood pressure during pregnancy)

- When a mother is carrying a baby that is dead

- When the placenta fails

- When menstruation stops

- Sleep disturbances

- Anxiety and stress

- Edema or swelling in the body

What does it mean if your b-Pregnanediol result is too high?

High levels of pregnanediol are associated with the following:

- Breast or ovarian cancer

- Adrenal gland dysfunction

- High levels of oral progesterone

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